Results 61 to 70 of about 52,339 (264)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Parametric Reform of Iranian Pension System with Imperfect Labor Market: Utilizing Replacement Rate Reduction and OLG Model Approach [PDF]
Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2019 Macroeconomic fluctuations and demographic changes have led to problems in Iranian retirement funds and lack of sustainability in their resources and expenditures. Because of ageing population and the effect of inflation on depreciation of pension funds’
Marzieh Bahmani +2 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Generalized overlap quantum state tomography
Physical Review Research, 2019 We propose and experimentally demonstrate a quantum state tomography protocol that generalizes the Wallentowitz-Vogel-Banaszek-W dkiewicz point-by-point Wigner function reconstruction. The full density operator of an arbitrary quantum state is efficiently reconstructed in the Fock basis, using semidefinite programming, after interference with a small ...
Rajveer Nehra +7 more
openaire +3 more sources
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Conspicuous Consumption and Overlapping Generations [PDF]
SSRN Electronic Journal, 2009 This paper investigates household decisions, and optimal taxation in an overlapping generations model in which individual utility depends on a weighted average of consumption of ones peers - a "keeping up with the Joneses'' consumption externality. In contrast to representative agent economies, the consumption externality generally affects steady state
openaire +4 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Quelques apologues relatifs à la théorie du capital et de l’intérêt
Œconomia, 2018 Why do economists tell us stories? To explain to us? To convince us? To demonstrate the proposals, they put forward? To try to answer this question, we will study the apologues that John Rae, Eugen von Böhm-Bawerk and Maurice Allais used to explain their
Alain Béraud
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source