Results 21 to 30 of about 159,098 (266)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Analysis of Green Land Changes to Building Land Using Geographic Information System (GIS) in Salatiga City from 2013 to 2019

open access: yesJournal of Applied Geospatial Information, 2020
The land is a crucial element in human life as space and resource. The development of a region will not be neglected by the use of land. Data from BPS Salatiga 2013 to 2019 shows an average increase in population reaching 1.45%.
Riska Vennithasari   +1 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

GIS-based Flood Susceptibility Mapping Using Overlay Method in Central Sulawesi

open access: yesForum Geografi, 2020
Central Sulawesi is the largest province on the Sulawesi island with a dominant sloping topographic condition and has a variety of soil types, flow density, land use and rainfall that makes this region vulnerable to flooding.
Rheinhart Christian Hutauruk   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Controlling Dilution in Multilayer Welding for Additive Manufacturing [PDF]

open access: yesArchives of Metallurgy and Materials
Functionally graded material is a type of material characterized by gradual variations in the chemical composition and structure over volume. Dilution is a major concern in producing such materials produced using welding techniques.
M. Emami, S.H. Elahi
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Sucesso cirúrgico da reparação de fístulas de LCR da base anterior do crânio por via endoscópica

open access: yesRevista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
Introdução: As fístulas de líquido cefalorraquidiano (LCR) são comunicações anormais entre o espaço subaracnóideu e a cavidade nasal e podem ser classificadas em espontâneas e traumáticas (incluindo as fístulas iatrogénicas). Várias técnicas e materiais
Joana Guincho   +4 more
doaj   +1 more source

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