Results 61 to 70 of about 348,068 (237)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Model Pemetaan Geospasial Kerentanan Kekeringan di Kabupaten Wonogiri, Jawa Tengah

open access: yesJurnal Ilmu Lingkungan
Bencana kekeringan merupakan kondisi kurangnya ketersediaan air untuk pemenuhan kebutuhan sehari-hari di suatu wilayah. Kerentanan kekeringan menjadi aspek penting dalam mengidentifikasi daerah yang berpotensi mengalami bencana kekeringan.
Anggit Novian Berlianto   +2 more
doaj   +1 more source

A P2P-based Communication Framework for Geo-Location Oriented Networks

open access: yesJournal of Telecommunications and Information Technology, 2019
This paper proposes a novel peer-to-peer communication framework to implement geographical location oriented networks, called G-LocON. Location-based services have been gaining in popularity, as proven by ridesharing and mobile games.
Takumi Miyoshi   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

SDN Technology and Industry Analysis and Strategy Recommendations for Telecom Operator

open access: yesDianxin kexue, 2015
Software defined networking(SDN)proposed a new concept of network design,which emphasized the separation of network control plane and forwarding plane.It made network architecture more open and encourage network innovation.The basic concept and ...
Yongbing Fan, Zhilan Huang
doaj  

Application of JXTA-overlay platform for secure robot control [PDF]

open access: yes, 2010
In this paper, we present the evaluation and experimental results of secured robot control in a P2P system. The control system is based on JXTA-Overlay platform.
Arnedo Moreno, Joan   +5 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Microstructural Evolution within the Interphase between Hardening Overlay and Existing Concrete Substrates

open access: yesApplied Sciences, 2017
This article presents the microstructural evolution within the interphase between a hardening overlay made of cement mortar and an existing concrete substrate.
Łukasz Sadowski, Damian Stefaniuk
doaj   +1 more source

Investigating overlay journals: introducing the RIOJA Project [PDF]

open access: yes, 2007
Introduces the RIOJA (Repository Interface to Overlaid Journal Archives) project, a 1-year partnership between UCL (University College London), Imperial College London, and the Universities of Glasgow, Cambridge and Cornell.
Moyle, M., Polydoratou, P.
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

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