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NR4A1‐Driven Granulosa Cell Ferroptosis Contributes to Obesity‐Related Ovarian Dysfunction and Metformin‐Mediated Ovarian Protection

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Schematic illustrating that NR4A1‐driven granulosa cell ferroptosis mediates obesity‐related ovarian dysfunction, while metformin‐mediated ovarian protection is achieved via suppression of the PI3K/AKT–NR4A1 ferroptotic signaling cascade. ABSTRACT Obesity triggers ovarian dysfunction and female infertility accompanied by granulosa cell damage ...
Huihui Wang, Chaoying Wang, Shuaishuai Guo, Guang Yang, Junnan Fang, Jingyi Hu, Ran Jiang, Jun Zhai, Haixia Jin, Wenyan Song, Senlin Shi, Xianju Huang, Lin Qi, Zhaoting Wu, Yan Liu, Ning Song, Xiangyang Zhang, Guidong Yao   +17 more
wiley   +1 more source

Optimization of emergency logistics for urban flooding with consideration of rainfall effects. [PDF]

Sci Rep
Zhang P, Zhang C, Zhang P, Yan X, Yang H.   +4 more
europepmc   +1 more source

Eupatilin Alleviates Acute Myocardial Ischemia‐Reperfusion Injury in Rats via the Akt/GSK‐3β Pathway by Targeting COXs

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
It has been reported that eupatilin exerts cardioprotective effects after myocardial ischemia‐reperfusion injury (MIRI). This study further found that Eupatilin alleviated acute MIRI in rats by specifically inhibiting cyclooxygenase enzymes (COXs) and activating the Akt/GSK‐3β pathway, providing a theoretical basis for the application of eupatilin in ...
Min Guo, Qianqian Li, Lili Ji
wiley   +1 more source

Decentralized and Network-Aware Task Offloading for Smart Transportation via Blockchain. [PDF]

Sensors (Basel)
Liang F.
europepmc   +1 more source

Analysis of Rutting Formation Mechanisms and Influencing Factors in Asphalt Pavements Under Slow-Moving Heavy Loads. [PDF]

Materials (Basel)
Li P, Fu J, Sun L, Yue J, Zang Q.
europepmc   +1 more source

Hybrid deep learning techniques for adaptive routing and congestion control in urban VANET for wireless mobile networking. [PDF]

Sci Rep
Maray M.
europepmc   +1 more source

A Hybrid Optimization Algorithm for Enhancing Transportation and Logistics Scheduling in IoT-Enabled Supply Chains. [PDF]

Sensors (Basel)
Jihad AA, Abdalkafor AS, Yassen ET, Aldhaibani OA.   +3 more
europepmc   +1 more source

Road traffic injuries in Southeast Asia: making journeys safer. [PDF]

Lancet Reg Health Southeast Asia
The Lancet Regional Health-Southeast Asia.
europepmc   +1 more source

Impact of electric vehicle charging demand on power distribution grid congestion. [PDF]

Proc Natl Acad Sci U S A
Li Y, Jenn A.
europepmc   +1 more source

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Influence of the overloaded vehicles elimination on the road pavement durability

International Conference on Road and Rail Infrastructure, 2018
Overloaded heavy vehicles is currently big issue in Europe. It is proved that overloading contributes to shortening the fatigue life of the pavement structure. To counteract this unfavourable phenomenon, effective tools for the elimination of overloaded vehicles should be developed, one of them being the use of Weigh-in-Motion (WIM) systems.
Piotr Burnos, Piotr Zielinski, Janusz Gajda   +2 more
exaly   +2 more sources