Results 41 to 50 of about 644,869 (286)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

The analysis of overloaded trucks in indonesia based on weigh in motion data (east of sumatera national road case study)

MATEC Web of Conferences, 2018
Overloaded trucks phenomena generally common in developing countries where the traffic control is poor. In Indonesia, the percentage of overloaded trucks can reach more than 60% in the total number of trucks and may be one of the substantial factors that
Jihanny Jongga, Subagio Bambang Sugeng, Hariyadi Eri Susanto   +2 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Congestion-aware Multi-agent Reinforcement Learning for Wildfire Evacuation Routing [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Conventional navigation systems often cause severe bottlenecks during mass wildfire evacuations by routing vehicles onto the same capacity-limited corridors while ignoring advancing flame fronts.
B. Raei, R. Safarzadeh, X. Wang
doaj   +1 more source

Counteracting to overloaded vehicles [PDF]

, 2015
Główną przyczyną znacznego skrócenia okresu użytkowania nawierzchni jest przekraczanie dopuszczalnych nacisków osi przez pojazdy ciężarowe, dlatego też Inspekcja Transportu Drogowego i Generalna Dyrekcja Dróg Krajowych i Autostrad podejmują działania, w ...
Nowak, P.
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Heavy-Duty Vehicle Recognition on Concrete Bridges Using a Multi-Stage Heterogeneous Vision Framework

Buildings
To address the challenges of accelerated deterioration of concrete bridges caused by overloaded vehicles, this paper proposes a multi-stage heterogeneous visual framework for overloaded vehicle identification.
Sulan Li, Wei Liu, Shibin Lin, Heyao Chen   +3 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Other title: Interstate Reciprocity Agreement Between the State of Nebraska and the State of Kansas

, 2010
application/pdf Date of last signature: 4/28/10.--Page 7. Includes First Amendment to the Declaration of Interstate Reciprocity Agreement Between the State of Nebraska and the State of Kansas. Legal Review Completed: 4/29/2010."This Reciprocity Agreement
Kansas. Division of Vehicles.
core   +1 more source

Nanostructured Lipid Carriers for the Formulation of Topical Anti-Inflammatory Nanomedicines Based on Natural Substances

Pharmaceutics, 2021
The main function of the skin is to protect the body from the external environment. However, the skin can undergo inflammatory processes, due to genetic, hormonal, or environmental factors.
Kézia Cristine Barbosa Ferreira, Ana Beatriz Caribé dos Santos Valle, Camila Quinetti Paes, Guilherme Diniz Tavares, Frederico Pittella   +4 more
doaj   +1 more source