Results 111 to 120 of about 2,301 (237)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Statistical analysis of tourist arrivals and overnight stays in the mountain resorts in Croatia from 2005 to 2014

, 2016
For Croatia, tourism is a significant economic activity and Croatia is one of the most visited tourist destinations. The offer is based on the sea, sun and natural beauty while additional facilities are still underdeveloped.
Tibljaš, Rebeka
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Tourist Arrivals and Overnight Stays in The Counties of The Republic of Croatia in The Period from 2012 to 2022

Osnovni cilj ovog završnog rada je prikazati stanje turizma u Republici Hrvatskoj u vremenskom razdoblju od 10 godina, odnosno, u vremenskom razdoblju od 2012. godine do 2022. godine.
Mičević, Dario
core   +1 more source

TOURIST ACCOMMODATION CAPACITY, TOURIST ARRIVALS, AND OVERNIGHT STAYS IN RESORTS ALONG ROMANIA’S COASTAL AREA, 2023–2024 [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
The main purpose of this paper is to identify and analyse the operational tourist accommodation capacity, as well as tourist arrivals and overnight stays by type of accommodation establishment, in the resorts situated in the Romanian coastal area ...
GHERGHINA LILIANA
doaj  

Increased Shoulder Arthroscopy Time Is Associated With Overnight Hospital Stay and Surgical Site Infection

, 2018
PURPOSE: The purpose of this study was to characterize the rates of short-term postoperative complications, readmissions, and overnight hospital stays as a function of shoulder arthroscopy procedure time.
David M. Dines, Dines, J. S., Schairer, W. W., Ranawat, A. S., Samuel A. Taylor, William W. Schairer, Taylor, S. A., Boddapati, V., Michael C. Fu, Fu, M. C., Anil S. Ranawat, Joshua S. Dines, Venkat Boddapati, Dines, D. M.   +13 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

REVIVAL OF TOURISM DEMAND IN THE POST COVID-19 PANDEMIC PERIOD - A STATISTICAL OVERVIEW IN ROMANIA [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development
The goal of this study is the analysis of the dynamics of tourist flow (domestic and inbound) in terms of tourist arrivals and overnight stays in Romania after the Covid-19 pandemic, using the statistical data provided by National Institute of Statistics.
Agatha POPESCU, Cristina TINDECHE, Alina MARCUTA, Liviu MARCUTA, Adelaida HONTUS, Mirela STANCIU, Daniela-Mirela PLESOIANU   +6 more
doaj  

Overnight care patterns following parental separation: Associations with emotion regulation in infants and young children

, 2020
Children living in a shared-time parenting arrangement following separation (also known as joint physical custody or dual residence) spend equal or near-equal amounts of day and night time with each parent.
McIntosh, Jennifer, Smyth, Bruce, Kelaher, Margaret   +2 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source