Results 121 to 130 of about 847,152 (333)

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Husserl, Language and the Ontology of the Act [PDF]

, 1987
The ontology of language is concerned with the relations between uses of language, both overt and covert, and other entities, whether in the world or in the mind of the thinking subject.
Smith, Barry
core  

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Associations between childhood maltreatment and overt aggression in depressed adolescents: the mediating effect of alexithymia and insomnia

Frontiers in Psychiatry
BackgroundOvert aggression may be associated with childhood maltreatment (CM), insomnia, and alexithymia, but the underlying mechanisms of these associations have not been fully explored in adolescents with major depressive disorder (MDD). Therefore, the
Jiawei Wang, Lewei Liu, Sanhua Zhou, Lili Zhao, Qianqian Wu, Tiantian Sun, Nali Zhang, Xuemei Wei, Lei Xia, Feng Zhao   +9 more
doaj   +1 more source

Taraldsen’s generalization in diachrony : evidence from a diachronic corpus [PDF]

, 2016
International audienceWe present the first large scale quantitative investigation of the syncretisation of verbal subject agreement in Medieval French and test a classic analysis which relates non-syncretic agreement and null subjects as parts of the ...
Crabbé, Benoît, Prévost, Sophie, Simonenko, Alexandra   +2 more
core   +2 more sources

Multi-Level Steganography: Improving Hidden Communication in Networks

, 2012
The paper presents Multi-Level Steganography (MLS), which defines a new concept for hidden communication in telecommunication networks. In MLS, at least two steganographic methods are utilised simultaneously, in such a way that one method (called the ...
Fraczek, Wojciech, Mazurczyk, Wojciech, Szczypiorski, Krzysztof   +2 more
core   +2 more sources

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Thyroid Function and Prevalence of Anti-Thyroperoxidase (TPO) and Anti-Thyroglobulin (Tg) Antibodies in Outpatients Hospital Setting in an Area with Sufficient Iodine Intake: Influences of Age and Sex

Acta Medica Iranica, 2013
In order to examine the prevalence of thyroid disease in a hospital outpatient setting, in an area of sufficient iodine intake, serum levels of TSH, T4, T3, anti-Tg and anti-TPO antibodies were examined in 909 individuals with an age range of 12.4 to 88 ...
Ioannis Legakis, Mina Manousaki, Stela Detsi, Dimitra Nikita   +3 more
doaj   +2 more sources

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Neuronal activity in the human lateral temporal lobe. II. Responses to the subjects own voice.

, 1989
We have recorded neuronal responses in the lateral temporal lobe of man to overt speech during open brain surgery for epilepsy. Tests included overt naming of objects and reading words or short sentences shown on a projector screen, repetition of tape ...
Creutzfeldt, O., Lettich, E., Ojemann, G.   +2 more
core   +1 more source