Results 191 to 200 of about 847,152 (333)

Primary and secondary stroke prophylaxis in children with sickle cell anemia: a meta-analysis. [PDF]

Blood Adv
Rangarajan HG, Mejias-Figueroa JA, Gehred A, Rodeghier M, DeBaun MR.   +4 more
europepmc   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Impact of Thyroid Hormone Imbalance on Electrocardiographic Parameters: Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Kłosowicz M, Urbańczuk M, Burbelka A, Gala-Błądzińska A, Balawender K.   +4 more
europepmc   +1 more source

Inactivation Rap2a in Endothelial Cell Prevents Pulmonary Fibrosis by Regulating Immune Microenvironment Through MAP4K4‐VCAM1 Signaling

Advanced Science, EarlyView.
We identified the endothelial RAP2A as a regulator of inflammatory endothelial activation in experimental lung fibrosis and suggest that targeting RAP2A‐mediated signaling may represent a potential strategy to modulate endothelial–immune crosstalk during fibrotic lung injury.
Xiaolan Zheng, Peng Yue, Kaiyu Zhou, Guidong Gong, Yue Zhang, Sha Lin, Xu Liu, Yanjiang Zheng, Siyuan Jing, Junling Guo, Yan Qi, Bi‐Sen Ding, Yimin Hua, Yifei Li   +13 more
wiley   +1 more source

An open dataset of multidimensional signals based on different speech patterns in pragmatic Mandarin. [PDF]

Sci Data
Zhao R, Bai Y, Zhang S, Zhu J, Liu H, Ni G.   +5 more
europepmc   +1 more source

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Comparison of overtly and covertly observed hand antisepsis adherence in the intensive care units of a referral hospital in Iran. [PDF]

GMS Hyg Infect Control
Zand F, Sanaei A, Asmarian N, Zarei F, Tabatabai A, Zandi R, Salami S, Shoja K.   +7 more
europepmc   +1 more source

Somatosensory attention identifies both overt and covert awareness in disorders of consciousness

Annals of Neurology, 2016
R. Gibson, S. Chennu, D. Fernández-Espejo, Lorina Naci, A. Owen, Damian Cruse   +5 more
semanticscholar   +1 more source

STING Agonist‐Modified Tumor Targeting Photosensitizer Remodels Cancer‐Associated Fibroblasts to Potentiate Photoimmunotherapy in Pancreatic Cancer

Advanced Science, EarlyView.
This carrier‐free, esterase‐responsive nanoaggregate integrates a mitochondria‐targeting photosensitizer with a non‐nucleotide STING agonist to achieve localized photoactivation and immune reprogramming. ICyM2 remodels tumor stroma, induces potent immunogenic cell death, and triggers intratumoral STING activation, collectively revitalizing the ...
Yixuan Zhang, Shankun Yao, Yihan Zhao, Saisai Zhu, Wen Fang, Ranran Yu, Naiwen Shi, Ruixin Zhang, Yin Zhang, Jiawei Liang, Ziying Zhang, Shijin Xu, Ziwei Zhang, Jiajun Zhang, Yukun Li, Xiaoxuan Han, Yuncong Chen, Shu Zhang, Ying Lv   +18 more
wiley   +1 more source

Fate of Brain Metastasis With Cerebrospinal Fluid Space Invasion Based on MRI Findings: Clinical Features and Factors Affecting Progression to Overt Leptomeningeal Metastasis. [PDF]

Brain Tumor Res Treat
Hong Y, Song H, Gwak HS, Dho YS, Shin SH, Yoo H, Wang KC.   +6 more
europepmc   +1 more source