Results 21 to 30 of about 468,068 (215)
Advanced Science, EarlyView.A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li +21 more
wiley +1 more source
Fat mass limits lower-extremity relative strength and maximal walking performance in older women [PDF]
, 2011 The purpose of this study was to determine if excess fat negatively affects relative strength and walking gait performance in overweight, older women. Twenty five older women (65 – 80 yr) were separated into normal weight (BMI \u3c 25 kg m−2 , n=11) and ...
Kralian, Rachel J. +2 more
core +2 more sources
Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich +8 more
wiley +1 more source
Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis
Advanced Science, EarlyView.Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard +13 more
wiley +1 more source
A Touch Enabled Hemodynamic and Metabolic Monitor
Advanced Science, EarlyView.This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi +19 more
wiley +1 more source
Advanced Science, EarlyView.The proposed working model for how adipocytes participate in cisplatin resistance in osteosarcoma. The adipocytes secret A1BG and stabilize NAMPT, leading to increased NAD⁺ levels and subsequent increased PARP1‐mediated DNA repair, resulting in cisplatin resistance in osteosarcoma finally.
Yonghui Liang +8 more
wiley +1 more source
An ecological systems approach to examining risk factors for early childhood overweight: findings from the UK Millennium Cohort Study [PDF]
, 2009 Objective: To use an ecological systems approach to examine individual-, family-, community- and area-level risk factors for overweight (including obesity) in 3-year-old children. Methods: A prospective nationally representative cohort study conducted in
Cole, T.J. +3 more
core
Advanced Science, EarlyView.Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu +20 more
wiley +1 more source
Peer Victimization in Overweight Adolescents and Its Effect on Their Self-Esteem and Peer Difficulties [PDF]
, 2019 This study has three objectives: to examine whether adolescents who perceive themselves as overweight differ from others in terms of offline victimization at school, cybervictimization, self-esteem, and difficulties relating to peers; to examine the ...
Núñez, Andrea +3 more
core +1 more source
Advanced Science, EarlyView.The waterlogging tolerance of allotetraploid Actinidia valvata is inherited from one of its diploid progenitors, which leads to subgenome expression dominance, mediated by complex mechanisms including altered chromatin accessibility and DNA methylation.
Xiaoli Hu +14 more
wiley +1 more source