Results 41 to 50 of about 327,081 (245)

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Population Trends & Obesity Patterns in the Philippines: A Window to the Obesity Epidemic in the Asia-Oceania Region

Journal of the ASEAN Federation of Endocrine Societies, 2014
Dr. Lee Kaplan, in his lecture at the recently concluded Postgraduate Course in Endocrinology (Harvard Medical School, Boston, MA, USA) described obesity as a very common and growing problem, with a complex physiology and clinically heterogenous picture,
Augusto D. Litonjua
doaj  

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, Accepted Article.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among long‐term HCQ users with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain OCT (SD‐OCT) for screening. Methods A systematic search of PubMed, Scopus,
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Sleep Alters the Velocity of Physiological Brain Pulsations in Humans

Advanced Science, EarlyView.
Sleep alters I/CSF oscillatory flow, driven by increased respiratory (29%) and vasomotor pulsation (21%) velocities, while cardiovascular pulsations decreased by (22%). Velocity is quantified using optical flow analysis of MREG data. Spectral power increases alongside these pulsations (spatial correlation, r = 0.35 and r = 0.39, respectively ...
Ahmed Elabasy, Heta Helakari, Tommi Väyrynen, Zalán Rajna, Niko Huotari, Lauri Raitamaa, Ville Isokoski, Matti Järvelä, Mika Kaakinen, Johanna Piispala, Mika Kallio, Vesa Korhonen, Tapio Seppänen, Vesa Kiviniemi   +13 more
wiley   +1 more source

Predictors of Overweight/Obesity Among Preschool Children in Arba Minch City, Southern Ethiopia: Does Consumption of Sweet Food Predispose to Overweight/Obesity?

International Journal of Public Health
ObjectivesChildhood overweight/obesity is a serious public health problem in the world today specially low-and-middle income countries like Ethiopia. This study aimed to assess the prevalence of overweight/obesity and associated factors among preschool ...
Simegn Wagaye Kefene, Tamirat Gezahegn Guyo, Darik Temesgen Assefa, Yilma Chisha, Muluken Bekele Sorrie   +4 more
doaj   +1 more source

A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis

Advanced Science, EarlyView.
This study identifies the odd‐chain fatty acid C19:0 as an endogenous ligand of GPR120 that promotes glucose homeostasis via Gαq signaling. In obesity, elevated palmitic acid suppresses endogenous C19:0 production through a miRNA–PPARα–HACL1 pathway, offering a promising direction for understanding the role of OCFAs in human health.
Yanting Hou, Yinghua Ma, Qin Liu, Dingling Ma, Yuxin Tong, Lili Xu, Xiaolong Chu, Jingzhou Wang, Maodi Liang, Mengyuan Zhao, Huizi Zhang, Yurui Su, Jianxin Xie, Cuizhe Wang, Jun Zhang   +14 more
wiley   +1 more source

Class profile and prevalence of overweight and obesity in adolescents – pilot study on the “Health Steps” project

Annales Academiae Medicae Silesiensis
Introduction: The study aimed to assess the prevalence of overweight and obesity in adolescents aged 11–13 and compare the body weight and body fat content of students in general and sports classes.
Agnieszka Białek-Dratwa, Elżbieta Szczepańska, Małgorzata Słoma-Krześlak, Wiktoria Staśkiewicz-Bartecka, Sylwia Jaruga-Sękowska, Justyna Nowak, Joanna Nieć-Leśniak, Olga Sobek, Agata Kiciak, Agnieszka Bielaszka, Oskar Kowalski   +10 more
doaj   +1 more source

Estudio y seguimiento nutricional en una población de ancianos de un centro geriátrico

European Journal of Investigation in Health, Psychology and Education, 2014
Valorar nutricionalmente al anciano nos va a permitir conseguir y mantener un buen estado nutricional en la población anciana. Objetivos: 1. Valoración del estado nutricional de la población. 2.
Laura Guzmán Díaz, Herminia López García de la Serrana, María Jesús Oliveras López   +2 more
doaj   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source