Results 31 to 40 of about 36,935 (226)

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Theileria annulata infects B-cells in sheep, which display lower dissemination potential compared to T. lestoquardi-infected ovine B-cells

Ticks and Tick-Borne Diseases
Theileria annulata and Theileria lestoquardi are deadly tick-borne parasites of cattle and sheep, respectively. These parasites are transmitted by Hyalomma ticks, and their geographical distributions partially overlap, with T.
Shahin Tajeri, Perle Latré de Laté, Johanneke D. Hemmink, Christina Vrettou, Gordon Langsley, W. Ivan Morrison   +5 more
doaj   +1 more source

Identifying hepatic genes regulating the ovine response to gastrointestinal nematodes using RNA-Sequencing

Frontiers in Genetics, 2023
Gastrointestinal nematode (GIN) infections are considered the most important disease of grazing sheep and due to increasing anthelmintic resistance, chemical control alone is inadequate.
Samantha Dixon, Niel A. Karrow, Emma Borkowski, Aroa Suarez-Vega, Paula I. Menzies, Delma Kennedy, Andrew S. Peregrine, Bonnie A. Mallard, Ángela Cánovas   +8 more
doaj   +1 more source

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

A mechanical evaluation of polyvinyl alcohol hydrogels for temporomandibular joint disc replacement

Frontiers in Physics, 2022
The temporomandibular joint (TMJ) is a bilateral ginglymoarthroidal joint containing a fibrocartilaginous disc which distributes compressive stress and reduces friction on the articulating surfaces of the joint.
Jason P. Kuiper, Christian M. Puttlitz, Christian M. Puttlitz, Christian M. Puttlitz, Jennifer E. Rawlinson, Ryan Dobbs, Kevin M. Labus   +6 more
doaj   +1 more source

Milkability in Dairy Species: A Comparative Field Study on Milk Flow Dynamics in Cattle, Buffaloes, Sheep, Goats, and Donkeys Using an Electronic Milk Meter

Dairy
Milk flow dynamics during mechanical milking are strongly influenced by species-specific mammary anatomy, milk partitioning between cisternal and alveolar compartments, and milking management.
Carlo Boselli, Antonella Chiariotti, Valentina D’Onofrio, Maria Concetta Campagna, Giuliano Palocci, Vittoria Lucia Barile, Antonio Borghese   +6 more
doaj   +1 more source

Ovicidal Effect on Haemonchus contortus of Extract Partitions Shrubby Plants of the Tropical Dry Forest and Potentially Active Compounds Identification by UHPLC-Q/Orbitrap/MS/MS

Applied Sciences, 2023
The in vitro anthelmintic effect of the extracts on Haemonchus contortus (H. contortus) of three forage species in the tropical dry forest is known; however, there is no information about the effects of the extract partitions, nor their chemical ...
Néstor Jaime Romero-Jola, Jaime Andrés Cubides-Cárdenas, Natalia Escobar, Mario J. Simirgiotis   +3 more
doaj   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

CARACTERÍSTICAS DO PARTO E INVOLUÇÃO UTERINA EM OVELHAS NATIVAS DO PANTANAL BRASILEIRO

Ciência Animal Brasileira, 2013
The aim of this study was to describe aspects of the parturition and uterine involution in native sheep from Brazilian Pantanal. Fifty-seven pluriparous ewes were used in this study.
Carlos E. Fernandes, Cristiane Fabiane Cigerza, Guilherme dos Santos Pinto, Cesar Miazi, Marcos Barbosa-Ferreira, Charles Ferreira Martins   +5 more
doaj   +1 more source