Results 31 to 40 of about 146,853 (289)

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Does Metformin combined with Clomiphene Citrate improve fertility related outcomes in Clomiphene resistant women with PCOS : a systematic review [PDF]

, 2014
Peer reviewedPublisher ...
Colleran, Rebecca, Gemmel, Ailsa, Gill, Sabraj, O’Brian, Helen, Poobalan, Amudha, Zanuri, Nurhazwani Bt   +5 more
core   +2 more sources

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Role of Sex Hormone Receptors in Ovulation

Taiwanese Journal of Obstetrics & Gynecology, 2005
Sex hormones including progestins, androgens, and estrogens produced de novo from cholesterol within the ovary play important roles in the growth and differentiation of reproductive tissues and in the maintenance of fertility.
Peng-Hui Wang
doaj   +1 more source

Mogroside V Improves Follicular Development and Ovulation in Young-Adult PCOS Rats Induced by Letrozole and High-Fat Diet Through Promoting Glycolysis

Frontiers in Endocrinology, 2022
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries.
Lan’e Huang, Aihong Liang, Tianlong Li, Xiaocan Lei, Xi Chen, Biyun Liao, Jinru Tang, Xiting Cao, Gang Chen, Fengyu Chen, Yiyao Wang, Linlin Hu, Weiguo He, Meixiang Li   +13 more
doaj   +1 more source

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

Advanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang   +11 more
wiley   +1 more source

Effect of L-carnitine supplementation on fertility outcomes among patients with polycystic ovary syndrome: a systematic review and dose-response meta-analysis of randomized clinical trials [PDF]

Obstetrics & Gynecology Science
This systematic review and meta-analysis of randomized controlled trials (RCTs) assessed the effect of L-carnitine (LC) supplementation on the fertility outcomes of patients with polycystic ovary syndrome (PCOS). Online databases (Scopus, Web of Science,
Ahmed Abu-Zaid, Ghadeer Adel Alghamdi, Alaa Saleh Alharbi, Saeed Baradwan, Saleh A K Saleh, Heba M Adly, Mooza M Alzayed, Mohammed Abuzaid, Raghad Sindi, Mohannad Alsabban, Osama Alomar   +10 more
doaj   +1 more source

Physiology and modulation factors of ovulation in rabbit reproduction management

World Rabbit Science, 2021
Rabbit is an induced ovulatory species, so ovulation takes place after mating. Traditionally, exogenous and synthetic hormonal factors (administered by intramuscular and intravaginal route) such as GnRH and analogues, or different physical procedures (i ...
Simona Mattioli, Margherita Maranesi, Cesare Castellini, Alessandro Dal Bosco, Maria Arias-Álvarez, Pedro Luis Lorenzo, Pilar García Rebollar, Rosa María García-García   +7 more
doaj   +1 more source

Efficacy and Efficiency in Natural Family Planning Services [PDF]

, 2009
Relatively few Catholic couples in the United States use modern methods of natural family planning (NFP). So too, few Catholic physicians and health professionals prescribe the use of NFP methods for their patients.
Fehring, Richard
core   +2 more sources

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source