Results 61 to 70 of about 136,516 (311)
Frontiers in Cell and Developmental Biology, 2023 Introduction: Preovulatory follicle response to the luteinizing hormone (LH) surge leads to metabolic, molecular, and functional changes in the oocyte and somatic follicular cells from the onset of estrus to ovulation.
Emma A. Hessock +12 more
doaj +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
Advanced Science, EarlyView.MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi +9 more
wiley +1 more source
Ovulation and rate of implantation following unilateral ovariectomy in mice
Journal of Human Reproductive Sciences, 2013 Objectives: Removal of an ovary of any side of the body is called the unilateral ovariectomy (ULO). ULO models are used to analyze the existence of functional and physiological asymmetries between the ovaries, including the ovum implantation.
Koushik Bhattacharya
doaj +1 more source
Vaginal stimulation enhances ovulation of queen ovaries treated using a combination of eCG and hCG
Veterinary Medicine and Science, 2021 Follicular changes throughout the oestrous phase have been poorly documented in queens because of the location and the small size of ovaries. We investigated follicular development in queens treated with a combination of equine chorionic gonadotropin ...
Naoaki Yoshimura +8 more
doaj +1 more source
Advanced Science, EarlyView.Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi +13 more
wiley +1 more source
Granulosa cell proliferation is inhibited by PGE2 in the primate ovulatory follicle
Animal Cells and Systems, 2020 Prostaglandin E2 (PGE2) is a key paracrine mediator of ovulation. Few specific PGE2-regulated gene products have been identified, so we hypothesized that PGE2 may regulate the expression and/or activity of a network of proteins to promote ovulation.
Patric S. Lundberg +5 more
doaj +1 more source
Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis [PDF]
Molecular and Cellular Endocrinology, 436:10--22 (2016), 2018 Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric modulators (NAMs) of follicle-stimulating hormone receptor (FSHR), ADX68692 and ADX68693, with differential effects on FSHR-mediated steroidogenesis and ovulation.
arxiv +1 more source
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +8 more
wiley +1 more source
Role of mTOR Signaling in Female Reproduction
Frontiers in Endocrinology, 2019 Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase of the phosphatidylinositol kinase-related kinase family that regulates cell growth, metabolism, and autophagy.
Zaixin Guo, Qi Yu
doaj +1 more source
Spider Eye Development Editing and Silk Fiber Engineering Using CRISPR‐Cas
Angewandte Chemie International Edition, Accepted Article.CRISPR‐Cas9 gene editing represents an effective and precise technology to induce mutations in the genome, and it has been applied to a wide range of organisms for diverse purposes. However, CRISPR‐based gene editing in spiders has not been reported to date.
Edgardo Santiago Rivera, Thomas Scheibel
wiley +1 more source