Results 211 to 220 of about 50,091 (300)

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal–Fetal Tolerance

open access: yesThe FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao   +3 more
wiley   +1 more source

Aptamer‐Functionalized Silicon Nanonet‐Based Field‐Effect‐Transistors Combined with Machine Learning for Real‐Time Detection of 17β‐Estradiol

open access: yesAdvanced Sensor Research, Volume 5, Issue 4, April 2026.
Schematic workflow of the BioFET (biological field‐effect transistor)based hormone sensing system, including (1) 17β‐estradiol (E2) sample preparation in PBS (phosphate‐buffered saline), (2) DNA aptamerfunctionalized BioFET sensing, (3) electrical signal acquisition (IV: currentvoltage characteristics), and (4) machine‐learning (ML)based data analysis.
Alexandra Parichenko   +9 more
wiley   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

open access: yesAdvanced Science, Volume 13, Issue 22, 17 April 2026.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang   +22 more
wiley   +1 more source

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

open access: yesAdvanced Science, Volume 13, Issue 23, 23 April 2026.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu   +11 more
wiley   +1 more source

Letrozole and clomiphene versus letrozole alone for ovulation induction in women with PCOS: a systematic review and meta-analysis. [PDF]

open access: yesRev Bras Ginecol Obstet
Eskandar K   +6 more
europepmc   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

open access: yesAdvanced Science, Volume 13, Issue 22, 17 April 2026.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu   +25 more
wiley   +1 more source

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