Results 121 to 130 of about 6,948,837 (250)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Developing LDers: a spotlight on resources and framework for the ALDinHE continuous professional development project

open access: yesJournal of Learning Development in Higher Education
How do learning developers (LDers), at all stages of their career, contribute to their own development, and that of LD colleagues? Our community is rich with knowledge, experience, innovation and creativity, with which it enhances the professional ...
Amy West, Samantha Thomas, Kate Coulson
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Successful ability to stay at home - an interview study exploring multiple diagnosed older persons and their relatives’ experiences

open access: yesBMC Geriatrics
Background Society places increased demands on regions and municipalities to jointly carry out activities for multi-diagnosed older persons with extensive coordination needs.
Lena-Karin Gustafsson   +3 more
doaj   +1 more source

Optimization Dispatch of Distribution Network–Prosumer Group–Prosumer Considering Flexible Reserve Resources of Prosumer

open access: yesEnergies
The bidirectional uncertainty of source and load creates scarcity in the reserve resources of the distribution network. Therefore, it is highly significant for the safe and economic operation of the system to harness spare energy storage capacity from ...
Hao Zhong   +4 more
doaj   +1 more source

Reforming Europe: “EU Shares” as an Own Resource

open access: yesInternational Business Research, 2016
Over time, the European Union’s financing system has attracted its fair share of harsh criticism. On the one hand, it is broadly agreed that the current collecting approach – relying on GNI-, VAT-based resources and other minor funding sources – is particularly complicated. Hence, communitarian policymakers have begun thinking of financing alternatives.
openaire   +1 more source

Herland Sister Resources : v.1: no.3(1985) [PDF]

open access: yes, 1985
The Herland Sister Resources newsletter is the monthly publication of Herland Sister Resources, a womanist organization with a strong lesbian focus based in Oklahoma ...
Herland Sister Resources
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Annual report (Online); Division of Mineral Resources Management annual report

open access: yes
Annual; Description based on: 2004; title from PDF cover (viewed Dec. 12, 2006).; Ohio Department of Natural Resources, Division of Mineral Resources Management is a result of the merger of Ohio Department of Natural Resources, Division of Mines and ...
Ohio. Division of Mineral Resources Management.
core   +1 more source

Herland Sister Resources : v.1: no.11(1985) [PDF]

open access: yes, 1985
The Herland Sister Resources newsletter is the monthly publication of Herland Sister Resources, a womanist organization with a strong lesbian focus based in Oklahoma ...
Herland Sister Resources
core  

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