Results 121 to 130 of about 7,866,988 (297)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Behind the sacred tree: local people and their natural resources sustain-ability

Reinwardtia, 2014
Local communities have their own means of maintaining their traditional know-ledge and sustaining the production system of natural resources by designating the resources as sacred.
Mohammad Royyani, Joeni Rahajoe
doaj  

Fostering Teachers’ Work Engagement: The Role of Emotional Self-Efficacy Toward One’s Own Emotions, Professional Self-Efficacy, and Job Resources

European Journal of Investigation in Health, Psychology and Education
The present cross-sectional study explored the synergic role of self-report measures of emotional self-efficacy toward one’s own emotions (i.e., the extent to which individuals perceive themselves as confident and effective in managing their emotions ...
Alessio Tesi, Andrea Baroncelli, Carolina Facci, Antonio Aiello, Enrica Ciucci   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Resource Allocation in Operator-owned Content Delivery Systems.

, 2016
QC ...
openaire   +3 more sources

A rational system of the own resources for the European Community

Economics and Business Review, 2005
A system of EC own resources needs a comprehensive reform because it does not correspond with the new reality of enlarged European Union (EU). The system analysis according to the own resources criteria in federal country proves that the present system of EC resources neither guarantees EC financial autonomy nor equity in taxation between Member States
openaire   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Developing LDers: a spotlight on resources and framework for the ALDinHE continuous professional development project

Journal of Learning Development in Higher Education
How do learning developers (LDers), at all stages of their career, contribute to their own development, and that of LD colleagues? Our community is rich with knowledge, experience, innovation and creativity, with which it enhances the professional ...
Amy West, Samantha Thomas, Kate Coulson
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source