Results 121 to 130 of about 7,523,363 (303)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Developing LDers: a spotlight on resources and framework for the ALDinHE continuous professional development project

Journal of Learning Development in Higher Education
How do learning developers (LDers), at all stages of their career, contribute to their own development, and that of LD colleagues? Our community is rich with knowledge, experience, innovation and creativity, with which it enhances the professional ...
Amy West, Samantha Thomas, Kate Coulson
doaj   +1 more source

Reforming Europe: “EU Shares” as an Own Resource

International Business Research, 2016
Over time, the European Union’s financing system has attracted its fair share of harsh criticism. On the one hand, it is broadly agreed that the current collecting approach – relying on GNI-, VAT-based resources and other minor funding sources – is particularly complicated. Hence, communitarian policymakers have begun thinking of financing alternatives.
openaire   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Successful ability to stay at home - an interview study exploring multiple diagnosed older persons and their relatives’ experiences

BMC Geriatrics
Background Society places increased demands on regions and municipalities to jointly carry out activities for multi-diagnosed older persons with extensive coordination needs.
Lena-Karin Gustafsson, Anna Bondesson, Tina Pettersson, Gunnel Östlund   +3 more
doaj   +1 more source

Optimization Dispatch of Distribution Network–Prosumer Group–Prosumer Considering Flexible Reserve Resources of Prosumer

Energies
The bidirectional uncertainty of source and load creates scarcity in the reserve resources of the distribution network. Therefore, it is highly significant for the safe and economic operation of the system to harness spare energy storage capacity from ...
Hao Zhong, Lanfang Li, Qiujie Wang, Xueting Wang, Xinghuo Wang   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

State-federal relationships in water resources development programs. [1956 - Bulletin 2]

, 1956
"Federal participation in the development of water resources projects and programs in the State of Kansas can be expected to approach a billion dollars... The over-all impact of these federal programs is tremendous.
Kansas. State Water Resources Board.
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mineral resources base of Ukraine. Article 4. Fuel and energy resources and perspectives of their capacity

Мінеральні ресурси України, 2015
In the article characterized the current state fuel and energy resources and perspectives of their capacity in accordance with the State Program on the development of mineral resources base of Ukraine for the period until 2030.
M. D. Krasnozhon
doaj