Results 81 to 90 of about 850,210 (308)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Cancer patients' perceptions of their own participation and own resources after receiving information about discontinuation of active tumour treatment

open access: yes, 2000
The focus of most studies on informational needs has been on primary cancer diagnosis. The aim of this study was to explore how cancer patients in a palliative care setting perceived their own participation and resources after receiving information about
Carlsson, Maria,   +2 more
core   +1 more source

Innovativeness and financial resources diversity of Slovenian early-stage enterpreneurs

open access: yesEkonomski Vjesnik, 2018
This paper focuses on the diversity of financial resources for Slovenian early-stage entrepreneurs. In the empirical study, we examined whether early-stage entrepreneurs with different characteristics regarding innovativeness also differ regarding the ...
Blaž Frešer, Polona Tominc
doaj  

Natural resources: an alternative used as a complementary therapy by people who live with virus/immune-deficiency acquired syndrome, Tampico Tamaulipas, México

open access: yesCultura de los Cuidados, 2012
Aims: Were centred in understanding and explaining the meaning of natural resources for those people living with AIDS, from the perspective of anthropology of care, at the same time to determine which are those resources and their effectiveness from the ...
Socorro Piñones Martínez   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Knowledge Organization Systems and Information Ethics for Visual Resources

open access: yes, 2020
This article examines the diverse problems current visual resources workflows and other information systems pose for Native American/Indigenous cultural heritage materials, using the concept of the knowledge organization system as a unit of analysis.
Murphy, Devon
core  

Tax-based Own Resources to Finance the EU Budget

open access: yes, 2019
In the current negotiations about the European Union's next medium-term Multiannual Financial Framework (MFF) for the period 2021 to 2027, the system of own resources financing EU expenditures plays a relatively important ...
Krenek, Alexander   +3 more
core   +1 more source

Couples’ Psychological Resources and Marital Satisfaction: The Mediating Role of Marital Support

open access: yesEurope's Journal of Psychology
The aim of this study was to assess the interdependent relations among psychological resources, marital support, and marital satisfaction in married couples from the perspective of both dyad members, using the Actor-Partner-Interdependence-Model (APIM ...
Keren Michael, Hasida Ben-Zur
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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