Results 61 to 70 of about 107,986 (266)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Relationship modeling of shareholders and management in the ecologically corporate governance [PDF]
Marketing i Menedžment Innovacij, 2012 Determine whether to use various models to determine the features of formation and evolution of the relationship between certain categories of contractors in business corporations.
T.V. Pimonenko
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Frontiers in Sustainable Food SystemsFarmworkers and farm owners both find themselves increasingly squeezed in the current labor landscape of Midwest agriculture, with workers facing precarious labor conditions and with owners struggling to find employees.
Marisa Lanker Paniello +1 more
doaj +1 more source
Owner-consumers and efficiency [PDF]
Economics Letters, 1985 Abstract If each household owns the same fraction of a firm as its share of consumption, shareholders unanimously want marginal-cost pricing. Otherwise, profits are overemphasised relative to consumer surplus.
openaire +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Owner-Reported Cohort Study of Causes, Management and Outcome of Traumatic Wounds in 219 Horses
AnimalsCurrent evidence on traumatic equine wounds are predominantly from expert opinion reviews or referral hospital studies. This study aimed to describe the owner-reported causes, management and outcome of equine wounds. An owner-reported cohort approach was
Richard Birnie +6 more
doaj +1 more source