Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Ownership structure and efficiency: An incentive mechanism approach [PDF]
Abstract We compare efficiency implications of two team production models involving problems of team moral hazard and adverse selection. The models, formalized in a generalized principal/multiple-agent framework, differ only in the underlying ownership structures, one characterized by absentee ownership, the other by cooperative ownership.
openaire +6 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The effects of ownership structure on corporate value in the Tehran Stock Exchange (TSE) [PDF]
In the present study, the separate and simultaneous role of concentration and type of ownership on corporate value is investigated. In this study, the ownership structure is classified into four classes: the institutional ownership, the corporate ...
Hossein Naderi, Sohrab Osta
doaj
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating the Effect of Ownership Structure on Audit Fees [PDF]
The purpose of this study is to evaluate the effect of ownership structure on the audit fees of listed companies in Tehran Stock Exchange. In this paper, the variables of family ownership, state ownership, institutional ownership and management ownership
Vali Khodadadi +2 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Ownership structure and corporate performance: empirical evidence of China’s listed property companies [PDF]
This paper investigates the relationship of ownership structure and corporate performance of China’s listed property companies. Data from all the listed property companies on China’s stock market from 2000 to 2002 were used to study ownership ...
Isaac, David +5 more
core +1 more source
Ownership structure and firm performance in Malaysia [PDF]
The aim of the study is to investigate the effect of different type of ownership structure on firm performance proxied by market measure (market to book value, MTBV) based on companies listed on Bursa Malaysia in the year 2006 to 2010.
Kamardin, Hasnah +2 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

