Results 11 to 20 of about 7,735 (257)
Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
International Journal of Molecular Sciences, 2021 Citrate plays a central role in cancer cells’ metabolism and regulation. Derived from mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate.
P. Icard +7 more
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Oxaloacetate Transport into Plant Mitochondria1 [PDF]
Plant Physiology, 1999 Abstract The properties of oxaloacetate (OA) transport into mitochondria from potato (Solanum tuberosum) tuber and pea (Pisum sativum) leaves were studied by measuring the uptake of14C-labeled OA into liposomes with incorporated mitochondrial membrane proteins preloaded with various dicarboxylates or citrate.
Katharina Baumgarten +3 more
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Designing and Constructing a Novel Artificial Pathway for Malonic Acid Production Biologically
Frontiers in Bioengineering and Biotechnology, 2022 Malonic acid is used as a common component of many products and processes in the pharmaceutical and cosmetic industries. Here, we designed a novel artificial synthetic pathway of malonic acid, in which oxaloacetate, an intermediate of cytoplasmic ...
Shuying Gu +4 more
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Oxaloacetate decarboxylases of rat liver [PDF]
Biochemical Journal, 1973 1. Two oxaloacetate decarboxylases of rat liver are described; one is mitochondrial with no metal ion requirement and activity in the alkaline pH region; the other is cytoplasmic with Mn2+or Mg2+requirement and activity around pH5. 2. A method for the partial purification of the mitochondrial enzyme is described. 3. The apparent Km of the mitochondrial
B. Dean, W. Bartley
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Some properties of oxaloacetate-synthesizing enzyme [PDF]
Biochemical Journal, 1959 R. G. Stickland
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Iron catalysis at the origin of life [PDF]
, 2017 Iron–sulphur proteins are ancient and drive fundamental processes in cells, notably electron transfer and CO2 fixation. Iron–sulphur minerals with equivalent structures could have played a key role in the origin of life. However, the ‘iron–sulphur world’
Camprubi Casas, Eloi +3 more
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The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
Cells, 2021 Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed by numerous cell-intrinsic and extrinsic factors.
E. Prochownik, Huabo Wang
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IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2020 This article presents a personal and critical review of the history of the malate–aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the oxidation of cytosolic NADH by the mitochondria in Ehrlich ...
P. Borst
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Pyruvate carboxylase and cancer progression
Cancer & Metabolism, 2021 Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the tricarboxylic acid (TCA) cycle.
Violet A. Kiesel +7 more
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Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway
Nature, 2013 Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes.
J. Son +17 more
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