Microbial Transformation of 3-Nitro-4-Hydroxybenzene Arsonic Acid (Roxarsone) [PDF]
, 2007 Land application of chicken litter from production houses that use the organoarsenical 3-nitro-4-hydroxybenzenearsonic acid (roxarsone) results in deposition of significant quantities of arsenic into United States soil each year.
Crable, Bryan
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Cyanide as a primordial reductant enables a protometabolic reductive glyoxylate pathway
Nature Chemistry, 2021 Investigation of prebiotic metabolic pathways is predominantly based on abiotically replicating the reductive citric acid cycle. While attractive from a parsimony point of view, attempts using metal/mineral-mediated reductions have produced complex ...
Mahipal Yadav +3 more
semanticscholar +1 more source
Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells
Biotechnology and Bioengineering, EarlyView.ABSTRACT Chinese hamster ovary (CHO) cells remain the industry standard for producing numerous therapeutic proteins, particularly monoclonal antibodies (mAbs). However, achieving higher recombinant protein titers remains an ongoing challenge and a fundamental understanding of the cellular mechanism driving improved bioprocess performance remains ...
Kate E. Meeson +9 more
wiley +1 more source
Biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya [PDF]
, 1996 This thesis describes results on the biosynthesis of fluoroacetate and 4-fluorothreonine by the bacterium Streptomyces cattleya. Exploratory (^14)C-radiolabelling experiments, designed to determine the relative incorporation of a range of metabolites ...
Amin, Muhammad Ruhul
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Metabolic routes in inflammation: the citrate pathway and its potential as therapeutic target.
Current Medicinal Chemistry, 2020 Significant metabolic changes occur in inflammation to respond to the new energetic needs of cells. Mitochondria are addressed not only to produce ATP, but also to supply substrates, such citrate, to produce pro-inflammatory molecules.
V. Infantino, C. Pierri, V. Iacobazzi
semanticscholar +1 more source
Biotechnology Progress, EarlyView.Abstract One strategy to enhance the production of biological therapeutics is using transient perfusion in the preculture (N‐1 stage) to seed the production culture (N stage) at ultra‐high cell densities (>10 x 106 viable cells/mL). This very high seeding density improves cell culture performance by shortening the timeline and/or achieving higher final
Lucas Lemire +5 more
wiley +1 more source
Energetics of the Citric Acid Cycle in the Deep Biosphere
Geophysical Monograph Series, Page 303-327., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Peter A. Canovas III, Everett L. Shock
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Quinolines from oxime o-acetates [PDF]
, 2004 The photochemistry of a number of arylidenecyclopentanone oxime 0 - acetates has been investigated Irradiation in methanol leads to initial E-Z geometrical isomérisation and ultimately to the formation of nitrogen containing heterocycles, via a 6îr ...
Tully, Ray
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Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism
PLoS Comput. Biol., 2014 In metabolism research, thermodynamics is usually used to determine the directionality of a reaction or the feasibility of a pathway. However, the relationship between thermodynamic potentials and fluxes is not limited to questions of directionality ...
E. Noor +5 more
semanticscholar +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source