Results 181 to 190 of about 2,441 (215)
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Synthesis and thermal study of the prodrug of oxamniquine

Journal of Thermal Analysis and Calorimetry, 2006
Oxamniquine polymeric prodrug with potential antischistosomal activity was prepared using dextran T-70 as a carrier, which was analysed by 1HNMR, 13C NMR and IR spectroscopy. The formation of the oxamniquine salt was confirmed by thermogravimetric analysis (TG) and differential scanning calorimetry (DSC) which showed a different thermal behaviour when ...
Almeida, A. E.   +4 more
openaire   +3 more sources

A comparative study on the genetic effects of hycanthone and oxamniquine

Journal of Toxicology and Environmental Health, 1975
Oxamniquine (UK-4271; 6-hydroxymethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetrahydroquinoline) is a new schistosomicidal agent currently undergoing clinical investigation in South America. Essentially a complete cure rate against Brazilian Schistosoma mansoni has been seen in adults with a single im dose of 7.5 mg/kg or a single oral dose of 15 mg ...
Martha L. Hyneck   +3 more
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A review of clinical experience with oxamniquine

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
Oxamniquine has now been in general use for 11 years for the treatment of schistosomiasis mansoni. Dosage varies with the geographical origin of the parasites due to different susceptibilities of local strains, and the appropriate regimen can be expected to cure over 80% of patients and reduce egg excretion in others by over 90%. The drug has been used
openaire   +3 more sources

Ultrasound and clinical investigation of hepatosplenic schistosomiasis: evaluation of splenomegaly and liver fibrosis four years after mass chemotherapy with oxamniquine.

American Journal of Tropical Medicine and Hygiene, 2006
The course of hepatosplenic schistosomiasis after mass chemotherapy with oxamniquine has been rarely reported. We report the effect of treatment in patients with advanced schistosomiasis mansoni living in area of Brazil highly endemic for this disease. A
G. Cota   +3 more
semanticscholar   +1 more source

The treatment of experimental schistosomiasis with a combination of oxamniquine and praziquantel

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1983
The object of the study was to identify any potential therapeutic advantage in using the two antischistosomal drugs, oxamniquine and praziquantel, in combination rather than separately, in the treatment of schistosomiasis. The efficacy of the drugs was studied in albino mice with mature Schistosoma mansoni infections.
Keith Whitby Brammer   +1 more
openaire   +3 more sources

Efficacy of alternating therapy with oxamniquine and praziquantel to treat Schistosoma mansoni in children following failure of first treatment.

American Journal of Tropical Medicine and Hygiene, 1991
Two hundred children infected with Schistosoma mansoni were treated with either 20 mg/kg oxamniquine or 60 mg/kg praziquantel. Cure rates (about 85%) were similar as was the percentage reduction (80%) in egg counts in uncured children. Treatment with the
Naftale Katz   +6 more
semanticscholar   +1 more source

Reaction of electrogenerated oxamniquine radical anion with glutathione

Journal of Electroanalytical Chemistry, 1998
Abstract Cyclic voltammetry was used to investigate the electrochemical reduction of oxamniquine at glassy carbon electrode in general, and the oxamniquine radical anion formed by the electrochemical reduction of oxamniquine in aqueous alkaline media in particular.
Abd-Elgawad Radi, Fathalla Belal
openaire   +2 more sources

Seizures and Electroencephalograph Changes Associated with Oxamniquine Therapy

The American Journal of Tropical Medicine and Hygiene, 1978
A Tanzanian man with a known seizure disorder was admitted to hospital for treatment of schistosomiasis mansoni. He suffered a grand mal seizure soon after the second dose of oxamniquine. This is the first recorded seizured associated with use of this drug.
openaire   +3 more sources

Spectrofluorimetric and Spectrophotometric Determination of Oxamniquine in Pharmaceuticals and Biological Fluids via Derivatization with 4‐Chloro‐7‐Nitrobenzo‐2‐oxa‐1,3‐Diazole (NBD‐Cl)

, 2009
Spectrophotometric and spectrofluorimetric methods were developed for the determination of oxamniquine (OXM). Both methods are based on coupling with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) in borate buffer of pH 7.6, and the reaction product ...
N. El-enany, N. Ahmida, F. Belal
semanticscholar   +1 more source

Convulsions after oxamniquine

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
D. Overbosch   +4 more
openaire   +3 more sources

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