Results 81 to 90 of about 4,265,820 (293)

Methane oxidation and emission in Lake Lugano (Southern Switzerland) : a lipid biomarker and isotopic approach [PDF]

, 2015
Methane is an important greenhouse gas in Earth's atmosphere. The sources of atmospheric methane are largely biogenic, being produced under anoxic conditions by methanogenic Archaea.
Blees, Hendrik Jan Reynier
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

AEROBIC OXIDATION OF ALKYLAROMATICS TO CORRESPONDING HYDROPEROXIDES CATALYSED BY N‐HYDROXY IMMIDES

, 2012
Different N-hydroxyphthalimide (NHPI) derivatives were investigated as catalyst for the aerobic oxidation of alkylaromatics, including cumene, phenylcyclohexane and ethylbenzene, leading to the corresponding hydroperoxides in good yields and high ...
MELONE, LUCIO, C. Punta, S. Prosperini
core  

Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes [PDF]

, 2014
Aims/hypothesis: Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP ...
Hamilton, D. Lee, Montagut , Gemma, Meakin, Paul J., Susan M. Jalicy, Meakin, PJ, D. Lee Hamilton, Dawn Bestow, Bestow, D, Hamilton, DL, Montagut, G, Michael L. J. Ashford, Jalicy, Susan M., Findlay, John A., Jalicy, SM, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, Montagut, Gemma, John A. Findlay, Gemma Montagut, Meakin, Paul J, Ashford, Michael L J, Bestow, Dawn, Findlay, John A, Jalicy, Susan M, Hamilton, David Lee, Findlay, JA, Paul J. Meakin   +26 more
core   +1 more source

Biological and Chemical Processes of Nitrate Reduction and Ferrous Oxidation Mediated by Shewanella oneidensis MR-1

Microorganisms
Iron, Earth’s most abundant redox-active metal, undergoes both abiotic and microbial redox reactions that regulate the formation, transformation, and dissolution of iron minerals.
Lingyu Hou, Xiangyu Bai, Zihe Sima, Jiani Zhang, Luyao Yan, Ding Li, Yongguang Jiang   +6 more
doaj   +1 more source

Determining the oxidative stability and quality of tiger nut (Cyperus esculentus) oil and its antioxidant activity during microwave heating

Revista Española de Nutrición Humana y Dietética, 2018
Introduction: The emphasis on high-oleic vegetable oils is prominent in human communities all over the world. That being said, the high level of monounsaturated fatty acid (oleic acid) in tiger nut (Cyperus esculentus) oil shows that it is resistant to ...
Atoosa Sobhani, Abdulkarim Sabo Mohammed, Fatemeh Ghobakhlou, Hasanah Mohd Ghazali   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

TiO₂-Photocatalyzed As(III) Oxidation and its Applicability to Water Treatment [PDF]

, 2006
Ingestion of arsenic (As) in drinking water can lead to several chronic illnesses, including bladder, lung, and skin cancers. Due to natural weathering reactions, As is present in many drinking water sources throughout the United States and other ...
Ferguson, Megan Alameda
core   +1 more source

Investigating the role of environmental conditions in the dispersion of elements (major, minor and trace) using geochemical interpretations and models in the sedimentary deposits of Qalikuh, Lorestan [PDF]

علوم زمین خوارزمی
Oil shales, as an important hydrocarbon source, require careful investigation in terms of the distribution of various elements. Geochemical models are a powerful tool for understanding the distribution of elements and the factors affecting them, and help
Amirsaeid Hosseini, Mehrab Rashidi, Seyedeh Akram Jooybari, Manuchehr Daryabandeh   +3 more
doaj