Results 41 to 50 of about 1,105,477 (244)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Oxidation of nitrobenzene by ozone in the presence of faujasite zeolite in a continuous flow gas–liquid–solid reactor [PDF]

, 2010
This work investigates the oxidation of nitrobenzene (NB) by ozone in the presence of faujasite zeolite. Experiments were carried out in a gas–liquid–solid reactor were ozone transfer and NB oxidation took place at the same time.
Debellefontaine, Hubert, Manero, Marie-Hélène, J. Reungoat, M. H. Manéro, Pic, J. S., Pic, Jean-Stéphane, Manero, M. H., Debellefontaine, H., Reungoat, J., H. Debellefontaine, Reungoat, Julien, J. S. Pic   +11 more
core   +1 more source

Speciation of OH reactivity above the canopy of an isoprene-dominated forest [PDF]

Atmospheric Chemistry and Physics, 2016
Measurements of OH reactivity, the inverse lifetime of the OH radical, can provide a top–down estimate of the total amount of reactive carbon in an air mass.
J. Kaiser, J. Kaiser, K. M. Skog, K. Baumann, S. B. Bertman, S. B. Brown, S. B. Brown, W. H. Brune, J. D. Crounse, J. A. de Gouw, J. A. de Gouw, J. A. de Gouw, E. S. Edgerton, P. A. Feiner, A. H. Goldstein, A. H. Goldstein, A. Koss, A. Koss, P. K. Misztal, T. B. Nguyen, K. F. Olson, J. M. St. Clair, J. M. St. Clair, J. M. St. Clair, A. P. Teng, S. Toma, P. O. Wennberg, P. O. Wennberg, R. J. Wild, R. J. Wild, L. Zhang, F. N. Keutsch   +31 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Loneliness, social support and cardiovascular reactivity to laboratory stress [PDF]

, 2007
Self-reported or explicit loneliness and social support have been inconsistently associated with cardiovascular reactivity (CVR) to stress. The present study aimed to adapt an implicit measure of loneliness, and use it alongside the measures of explicit ...
Gidron, Y.Y., Nausheen, Bina, Gregg, A., Peveler, L., Peveler, Robert, Nausheen, B., Tissarchondou, Harilaos S., Gregg, Aiden, Tissarchondou, H., Gidron, Yori   +9 more
core   +1 more source

Comparison of analytical methods for monitoring autoxidation profiles of authentic lipids

Journal of Lipid Research, 1987
Oxidation profiles of polyunsaturated fatty acids, their esters, and fatty alcohols were compared by several commonly employed analytical procedures. The extent of lipid peroxidation varied with the structure of the specific lipid class.
R S Kim, F S LaBella
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

2-Iodo-N-isopropyl-5-methoxybenzamide as a highly reactive and environmentally benign catalyst for alcohol oxidation

Beilstein Journal of Organic Chemistry, 2018
Several N-isopropyliodobenzamides were evaluated as catalysts for the oxidation of benzhydrol to benzophenone in the presence of Oxone® (2KHSO5·KHSO4·K2SO4) as a co-oxidant at room temperature.
Takayuki Yakura, Tomoya Fujiwara, Akihiro Yamada, Hisanori Nambu   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source