Results 171 to 180 of about 18,437,504 (248)

Disproportionation and Ligand Lability in Low Oxidation State Boryl-Tin Chemistry. [PDF]

Chemistry, 2023
Zheng X, Crumpton AE, Protchenko AV, Heilmann A, Ellwanger MA, Aldridge S.   +5 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Bridgmanite's ferric iron content determined Earth's oxidation state. [PDF]

Nat Geosci
Wang F, Wang L, Fei H, Miyajima N, McCammon C, Frost DJ, Katsura T.   +6 more
europepmc   +1 more source

Composition Based Oxidation State Prediction of Materials Using Deep Learning Language Models. [PDF]

Adv Sci (Weinh), 2023
Fu N, Hu J, Feng Y, Morrison G, Loye HZ, Hu J.   +5 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

A Series of Trigonal Arylimido Iron Complexes and the Influence of Oxidation State and Steric Demand on Reactivity. [PDF]

Inorg Chem
Gonzalez A, Reith S, Reckziegel A, Werncke CG.   +3 more
europepmc   +1 more source

Data-Driven Predetermination of Cu Oxidation State in Copper Nanoparticles: Application to the Synthesis by Laser Ablation in Liquid. [PDF]

J Am Chem Soc, 2023
Miao R, Bissoli M, Basagni A, Marotta E, Corni S, Amendola V.   +5 more
europepmc   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Force-Triggered Thermodynamically Uphill Disulfide Reduction through Sulfur Oxidation State Control. [PDF]

J Am Chem Soc
Mora M, Cohen G, Cranton W, Anton O, Beedle AEM, Stirnemann G, Garcia-Manyes S.   +6 more
europepmc   +1 more source

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova, Jan Smeitink, Herma Renkema, Rosabeth White, Frankie Barton, Rachel Lyon, Jane Newman, Aye Moe, Yi Shiau Ng, Grainne Siobhan Gorman   +9 more
wiley   +1 more source