Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. [PDF]
, 1989 Uttam Garg, Aviv Hassid
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Magnetically tuned thermoelectric properties of metal-oxides: a review
Materials Research ExpressIn recent years, research on thermoelectric materials has garnered considerable attention, owing to their potential to offer efficient and environmentally friendly energy solutions.
Divya Prakash Dubey +1 more
doaj +1 more source
Difference in High-Temperature Tribological Performance of Oxide/Ag-MoS2-Based Composites
LubricantsMoS2 has excellent vacuum lubricating performance. However, it is prone to be oxidized in a high-temperature atmospheric environment, leading to the deterioration of its lubricating performance and even serious space accidents.
Yufei Wang +5 more
doaj +1 more source
Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands [PDF]
, 2011 Heather M. O’Hagan +12 more
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Oxides and oxide superconductors :
, 1991 Using both measurements and modeling, the elastic and related properties of some oxides and oxide superconductors were studied. The polycrystal elastic constants were measured using a MHz-frequency pulse-echo method between 295 and 4 K and corrected to the void-free state by using a model for a composite material containing spherical particles.
Ming Lei, Hassel Ledbetter
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion [PDF]
, 2011 Chenell Donadee +16 more
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