Results 311 to 320 of about 89,126 (347)

Oxidized low-density lipoprotein in postmenopausal women

Journal of Hypertension, 2014
Oxidized low-density lipoprotein (oxLDL) leads to atherosclerosis and cardiovascular disease, the most frequent causes of death worldwide. After menopause, lipid and lipoprotein metabolism changes and women are at greater risk of cardiovascular disease compared to fertile women.
Felix, Kork, Vera, Jankowski, Alexander R, Just, Johannes, Pfeilschifter, Martin, Tepel, Walter, Zidek, Joachim, Jankowski   +6 more
openaire   +3 more sources

Oxidation of lipids in low density lipoprotein particles

Free Radical Research, 1998
This study was undertaken to understand further the mechanisms and dynamics of the oxidation of lipids in low density lipoprotein (LDL) particles, aiming specifically at elucidating the material balance between oxygen uptake and products found and also the relative susceptibilities to oxidation of cholesteryl ester in the core and phosphatidylcholine ...
N, Noguchi, R, Numano, H, Kaneda, E, Niki   +3 more
openaire   +2 more sources

An endothelial receptor for oxidized low-density lipoprotein

Nature, 1997
Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial ...
T, Sawamura, N, Kume, T, Aoyama, H, Moriwaki, H, Hoshikawa, Y, Aiba, T, Tanaka, S, Miwa, Y, Katsura, T, Kita, T, Masaki   +10 more
openaire   +2 more sources

Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis

Atherosclerosis, 1998
Malondialdehyde (MDA)-modified and oxidized low density lipoproteins (LDL) have been demonstrated in atherosclerotic lesions. Elevated titers of autoimmune antibodies specific for MDA-modified LDL predicted the progression of carotid atherosclerosis and of myocardial infarction.
P, Holvoet, D, Collen
openaire   +2 more sources

Oxidized low-density lipoprotein-induced apoptosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Cultured cells are able to oxidize low-density lipoproteins (LDL) and oxidized LDL (oxLDL), which are present in atherosclerosis areas, exhibit a variety of biological properties potentially involved in atherogenesis. This review is focused on the toxicity of oxLDL, more precisely on the toxic compounds generated during LDL oxidation, the features and ...
Robert, Salvayre, Nathalie, Auge, Herve, Benoist, Anne, Negre-Salvayre   +3 more
openaire   +2 more sources

Inhibition of oxidation of low density lipoprotein by troglitazone

Atherosclerosis, 1996
The effect of a new oral hypoglycemic agent troglitazone, (+/-)-5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benz yl]-2,4-thiazolidinedione as an antioxidant against the free radical-mediated oxidation of low density lipoprotein (LDL) was studied.
N, Noguchi, H, Sakai, Y, Kato, J, Tsuchiya, Y, Yamamoto, E, Niki, H, Horikoshi, T, Kodama   +7 more
openaire   +2 more sources

The effect of EDTA on the oxidation of low density lipoprotein

Atherosclerosis, 1992
Low density lipoprotein (LDL) is routinely isolated and stored in buffers containing ethylene-diaminetetra-acetic acid (EDTA) to inhibit its autoxidation. We have investigated the effect of EDTA on LDL oxidation by both copper ions and macrophages.
D J, Lamb, D S, Leake
openaire   +2 more sources

Antioxidant vitamins and low-density-lipoprotein oxidation

The American Journal of Clinical Nutrition, 1993
Low-density-lipoprotein (LDL) oxidation was examined in 22 subjects (10 men, 12 women) after a daily dose of 18 mg beta-carotene, 900 mg vitamin C, and 200 mg alpha-tocopherol for 6 mo. Control subjects (12 men, 11 women) took no vitamin supplements. After 3-mo supplementation plasma concentrations of beta-carotene, alpha-tocopherol, and ascorbic acid ...
M, Abbey, P J, Nestel, P A, Baghurst
openaire   +2 more sources

Oxidized low-density lipoprotein biomarkers in atherosclerosis

Current Atherosclerosis Reports, 2006
The concept that the oxidation of lipoproteins is central in the pathogenesis of atherosclerosis was first reported over 25 years ago, initially by in vitro studies and subsequently through experimental models of atherosclerosis. The innate immune system plays a key role in atherogenesis as manifested by its atherosclerosis-modulating properties, the ...
openaire   +2 more sources

Evaluation of Oxidized Low-Density Lipoprotein and Large Molecular Size Low-Density Lipoproteins in Atherosclerosis

Pathobiology, 1993
To study the roles of modified low-density lipoprotein (LDL) and the molecular size of LDL in atherogenesis, the following studies were carried out. Eight white male rabbits fed a standard oriental diet with 1% cholesterol were used to isolate LDL and to observe changes in the molecular size of LDL due to cholesterol feeding.
T, Kanazawa, T, Osanai, T, Uemura, K, Onodera, Y, Oike   +4 more
openaire   +2 more sources