Results 251 to 260 of about 85,473 (301)
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Receptors for oxidized low density lipoprotein
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 1999An increasing body of evidence indicates that oxidized low density lipoprotein (LDL) is involved in the pathogenesis of atherosclerosis. One of the first biologic actions of oxidized LDL to be identified in vitro was its ability to interact with the 'acetyl LDL receptor' discovered by Goldstein and Brown. Over the past decade, considerable progress has
U P Steinbrecher
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Oxidized low-density lipoprotein and atherosclerosis
International Journal of Clinical & Laboratory Research, 1996Atherosclerosis is the leading cause of morbidity and mortality in western society. The most important risk factors for atherosclerosis include smoking, hypertension, dyslipidemia, diabetes and a family history of premature atherosclerosis. Several studies indicate that an increased plasma low density lipoprotein (LDL) cholesterol constitutes a major ...
S, Devaraj, I, Jialal
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Nitric Oxide and Low-Density Lipoprotein Oxidation
Free Radical Research, 1998Nitric oxide can have both pro-oxidant and antioxidant effects on low-density lipoprotein. Nitric oxide does not appear to react directly with components of LDL. However, in the presence of oxygen (through NO2 and N2O3 formation) or superoxide (through peroxynitrite formation) nitric oxide may cause oxidation of the lipid, protein and antioxidant ...
N, Hogg, B, Kalyanaraman
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Oxidation of lipoprotein Lp(a). A comparison with low-density lipoproteins
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991Aimed at identifying possible mechanisms of the suggested high atherogenicity of Lp(a), its susceptibility for Cu(II)-induced oxidation was studied and compared with that of LDL. Since the content of antioxidants as well as the fatty acid pattern of a lipoprotein greatly affects its oxidizability, Lp(a) and LDL were characterized first with respect to ...
W, Sattler +3 more
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High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990Oxidatively modified low-density lipoprotein (LDL), generated as a result of incubation of LDL with specific cells (e.g., endothelial cells, EC) or redox metals like copper, has been suggested to be an atherogenic form of LDL. Epidemiological evidence suggests that higher concentrations of plasma high-density lipoprotein (HDL) are protective against ...
S, Parthasarathy, J, Barnett, L G, Fong
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Inhibition of Low-Density Lipoprotein and High-Density Lipoprotein Oxidation by Raloxifene
Journal of Women's Health, 2004Raloxifene (RX), a selective estrogen receptor modulator (SERM), has demonstrated hypolipidemic and in vitro antioxidant properties. In the pathogenesis of atherosclerosis, the oxidative modification of low-density lipoprotein (LDL) is implicated to play a crucial role.In this study, we investigated the antioxidant properties of RX during in vitro LDL ...
Ulrike, Resch +3 more
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Oxidized Low-Density Lipoprotein Is Not Equal to Oxidative Stress
The American Journal of Cardiology, 2008Contains fulltext : 69022tits.pdf (Publisher’s version ) (Closed access)
Tits, L.J.H. van, Stalenhoef, A.F.H.
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Low-density lipoprotein oxidation in essential hypertension
Journal of Hypertension, 1993To investigate the occurrence of enhanced low-density lipoprotein (LDL) oxidation as an additional factor promoting atherosclerosis progression in hypertensive patients.The oxidation of plasma LDL was investigated in a group of untreated patients with mild-to-moderate essential hypertension without clinically evident target organ damage and in a group ...
Maggi E +5 more
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Chromium and human low-density lipoprotein oxidation
Journal of Trace Elements in Medicine and Biology, 2020Chromium is a catalytic metal able to foster oxidant damage, albeit its capacity to induce human LDL oxidation is to date unkown. Thus, we have investigated whether trivalent and hexavalent chromium, namely Cr(III) and Cr(VI), can induce human LDL oxidation. Cr(III) as CrCl3 is incapable of inducing LDL oxidation at pH 7.4 or 4.5.
Domenico Lapenna, Giuliano Ciofani
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Oximes as inhibitors of low density lipoprotein oxidation
Life Sciences, 2008Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis.
Rafael, de Lima Portella +6 more
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