Results 261 to 270 of about 85,473 (301)

Low density lipoprotein oxidation, antioxidants, and atherosclerosis

Current Opinion in Cardiology, 2000
Oxidized low density lipoproteins (LDLs) are believed to be the most atherogenic form of LDL. However, although a number of experimental data support this concept, the protective role of antioxidants that may prevent LDL oxidation in atherosclerosis is only partially confirmed by studies in humans.
A L, Catapano, F M, Maggi, E, Tragni
openaire   +2 more sources

Low-density lipoprotein oxidation.

Italian heart journal : official journal of the Italian Federation of Cardiology, 2001
Free radical mediated oxidation of low-density lipoproteins (LDL), which has been extensively studied in the last two decades, plays a central role in the development of the atherosclerotic plaque. Oxidation involves the lipid moiety of LDL in a chain reaction mechanism.
IULIANO, Luigi, MICHELETTA F, VIOLI, Francesco   +2 more
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Scavenger receptors and oxidized low density lipoproteins

Clinica Chimica Acta, 1999
Oxidized LDL has been shown to exhibit a number of potentially proatherogenic actions and properties, including receptor-mediated uptake and lipid accumulation within macrophages. It has been postulated that rapid, unregulated uptake of oxidatively modified LDL could account for the transformation of monocyte-derived macrophages to foam cells in ...
B S, Dhaliwal, U P, Steinbrecher
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Effects of phosphatidylserine on the oxidation of low density lipoprotein

International Journal of Biochemistry, 1994
1. LDL was incubated in the presence of 1 microM CuSO4 for 18 hr at 37 degrees C. The content of lipoperoxides was found to be approx. 40 nmol MDA equivalents/mg LDL protein. The addition of 50 microM phosphatidylserine (PS) reduced the content of lipoperoxides to 15% of control values. 2.
P, Lou, R L, Gutman, F W, Mao, P, Greenspan   +3 more
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Oxidation of low-density lipoprotein by hemoglobin–hemichrome

The International Journal of Biochemistry & Cell Biology, 2003
Hemoglobin and myoglobin are inducers of low-density lipoprotein oxidation in the presence of H(2)O(2). The reaction of these hemoproteins with H(2)O(2) result in a mixture of protein products known as hemichromes. The oxygen-binding hemoproteins function as peroxidases but as compared to classic heme-peroxidases have a much lower activity on small ...
Vladimir Varlen, Bamm, Vladimir Abraham, Tsemakhovich, Nurith, Shaklai   +2 more
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Oxidized low-density lipoprotein in postmenopausal women

Journal of Hypertension, 2014
Oxidized low-density lipoprotein (oxLDL) leads to atherosclerosis and cardiovascular disease, the most frequent causes of death worldwide. After menopause, lipid and lipoprotein metabolism changes and women are at greater risk of cardiovascular disease compared to fertile women.
Felix, Kork, Vera, Jankowski, Alexander R, Just, Johannes, Pfeilschifter, Martin, Tepel, Walter, Zidek, Joachim, Jankowski   +6 more
openaire   +3 more sources

Oxidation of lipids in low density lipoprotein particles

Free Radical Research, 1998
This study was undertaken to understand further the mechanisms and dynamics of the oxidation of lipids in low density lipoprotein (LDL) particles, aiming specifically at elucidating the material balance between oxygen uptake and products found and also the relative susceptibilities to oxidation of cholesteryl ester in the core and phosphatidylcholine ...
N, Noguchi, R, Numano, H, Kaneda, E, Niki   +3 more
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An endothelial receptor for oxidized low-density lipoprotein

Nature, 1997
Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial ...
T, Sawamura, N, Kume, T, Aoyama, H, Moriwaki, H, Hoshikawa, Y, Aiba, T, Tanaka, S, Miwa, Y, Katsura, T, Kita, T, Masaki   +10 more
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Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis

Atherosclerosis, 1998
Malondialdehyde (MDA)-modified and oxidized low density lipoproteins (LDL) have been demonstrated in atherosclerotic lesions. Elevated titers of autoimmune antibodies specific for MDA-modified LDL predicted the progression of carotid atherosclerosis and of myocardial infarction.
P, Holvoet, D, Collen
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Oxidized low-density lipoprotein-induced apoptosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Cultured cells are able to oxidize low-density lipoproteins (LDL) and oxidized LDL (oxLDL), which are present in atherosclerosis areas, exhibit a variety of biological properties potentially involved in atherogenesis. This review is focused on the toxicity of oxLDL, more precisely on the toxic compounds generated during LDL oxidation, the features and ...
Robert, Salvayre, Nathalie, Auge, Herve, Benoist, Anne, Negre-Salvayre   +3 more
openaire   +2 more sources