Results 271 to 280 of about 85,473 (301)
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Inhibition of oxidation of low density lipoprotein by troglitazone
Atherosclerosis, 1996The effect of a new oral hypoglycemic agent troglitazone, (+/-)-5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benz yl]-2,4-thiazolidinedione as an antioxidant against the free radical-mediated oxidation of low density lipoprotein (LDL) was studied.
N, Noguchi +7 more
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The effect of EDTA on the oxidation of low density lipoprotein
Atherosclerosis, 1992Low density lipoprotein (LDL) is routinely isolated and stored in buffers containing ethylene-diaminetetra-acetic acid (EDTA) to inhibit its autoxidation. We have investigated the effect of EDTA on LDL oxidation by both copper ions and macrophages.
D J, Lamb, D S, Leake
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Antioxidant vitamins and low-density-lipoprotein oxidation
The American Journal of Clinical Nutrition, 1993Low-density-lipoprotein (LDL) oxidation was examined in 22 subjects (10 men, 12 women) after a daily dose of 18 mg beta-carotene, 900 mg vitamin C, and 200 mg alpha-tocopherol for 6 mo. Control subjects (12 men, 11 women) took no vitamin supplements. After 3-mo supplementation plasma concentrations of beta-carotene, alpha-tocopherol, and ascorbic acid ...
M, Abbey, P J, Nestel, P A, Baghurst
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Oxidized low-density lipoprotein biomarkers in atherosclerosis
Current Atherosclerosis Reports, 2006The concept that the oxidation of lipoproteins is central in the pathogenesis of atherosclerosis was first reported over 25 years ago, initially by in vitro studies and subsequently through experimental models of atherosclerosis. The innate immune system plays a key role in atherogenesis as manifested by its atherosclerosis-modulating properties, the ...
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Assessment of Susceptibility of Low-Density Lipoprotein to Oxidation
2003It is now recognized that oxidation of low-density lipoprotein (LDL) is a key event in the development of atherosclerosis (1). In vivo, oxidation is believed to occur primarily in the arterial wall. In early atherosclerotic lesions oxidation may be initiated by enzymes, including myeloperoxidase and 15-lipoxygenase, or by reactive nitrogen species ...
J, McEneny, I S, Young
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Physiological aspects of low-density lipoprotein oxidation
Current Opinion in Lipidology, 2000The oxidation of LDL is thought to be a major contributor to the development of atherosclerosis. Considerable descriptive evidence has been accumulated showing that oxidized LDL promotes pro-atherogenic events. However, direct evidence that oxidized LDL causes atherosclerosis is lacking.
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Is oxidized low‐density lipoprotein present in vivo?
Current Opinion in Lipidology, 1998Basic research has provided strong evidence that oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Several mechanisms have been identified which can lead to LDL oxidation in vivo. Clinical and epidemiological studies have provided circumstantial evidence that oxidized LDL, as measured by serum autoantibody levels, may be ...
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Physical changes of low-density lipoprotein on oxidation
Chemistry and Physics of Lipids, 1993Human LDL samples from different individuals were oxidized in three different ways. All oxidized LDL samples exhibited lower temperature of the thermotropic transition and lower content of the helical fraction of apoprotein B than the related native LDL. The observed decrease of the thermotropic transition temperature was up to 2 degrees C.
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OXIDIZED LOW DENSITY LIPOPROTEIN
Journal of Hypertension, 2000J. Jankowski +4 more
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