Results 261 to 270 of about 63,046 (336)

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Association of lipoprotein(a), oxidized phospholipids and apolipoprotein B100 in acute ischemic stroke cohort. [PDF]

Adv Lipoprotein A Res
Li Y, Then E, Rahman S, Matienzo N, Matveyenko A, Pavlyha M, Khasiyev F, Marshall RS, Willey J, Gutierrez J, Reyes-Soffer G.   +10 more
europepmc   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Lipoprotein(a) and Cardiovascular Disease: From Genetic Risk Factor to Therapeutic Target. [PDF]

Cells
Yun HR, Singh MK, Han S, Ranbhise JS, Ha J, Kim SS, Kang I.   +6 more
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Lands' Cycle at the Crossroads: Phospholipid Remodelling, Oxidative Stress, Cellular Toxicity, and Therapeutic Targeting. [PDF]

ACS Pharmacol Transl Sci
Roggero A, Toyama MH, Sousa SF.
europepmc   +1 more source

Synthesis and Functional Properties of Fluorinated Phosphonate‐Substituted Porphyrins: Excellent Photosensitizers and Robust Precursors for Photoactive Langmuir–Schaefer Films

Chemistry – A European Journal, EarlyView.
This is a comprehensive study of new family of high functionalized meso‐tetraarylporphyrins. A synthetic approach to phosphonate‐substituted fluorinated porphyrins was developed. These compounds were investigated with respect to singlet oxygen generation and photostability.
Azhar Kechiche, Cyrille Monnereau, Chantal Andraud, Alla Bessmertnykh‐Lemeune, Yoann Rousselin, Andrey V. Cheprakov, Elizaveta V. Ermakova, Alexandra I. Zvyagina, Habib Nasri   +8 more
wiley   +1 more source

Photodynamic therapy simultaneously induces ferroptosis- and apoptosis-like lipid signatures in ovarian cancer cells. [PDF]

Cell Death Dis
Overchuk M, Choi AM, Rickard BP, Schnoor B, Ehrmann BM, Girotti AW, Zaharoff DA, Huang HC, O'Connell TM, Gomez SM, Rizvi I.   +10 more
europepmc   +1 more source

Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. [PDF]

J Med Chem, 2012
Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum JL, VanNieuwenhze MS.   +5 more
europepmc   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source