Results 291 to 300 of about 63,046 (336)
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Oxidized phospholipids in cardiovascular disease
Nature Reviews Cardiology, 2023Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic inflammation. OxPLs are present in atherosclerotic lesions and can be detected in plasma on apolipoprotein B (apoB)-containing lipoproteins. When initially conceptualized, OxPL-apoB measurement in plasma was expected to reflect the concentration of minimally oxidized ...
Sotirios Tsimikas, Joseph L. Witztum
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Phospholipid oxidation in emulsions
Lipids, 1970AbstractThe autoxidation of purified phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC), extracted from egg and soybean lipids, was followed by oxygen uptake measurements in emulsified systems. All emulsified phospholipid fractions had comparable activation energies.
G A, Corliss, L R, Dugan
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Oxidized phospholipids, isolevuglandins, and atherosclerosis
Molecular Nutrition & Food Research, 2005Autoxidation of polyunsaturated phosphatidylcholines (PCs) generates isolevuglandins (isoLGs) through rearrangements of isoprostanoid endoperoxides. Within seconds, isoLGs are sequestered by covalent adduction with proteins. Murine plasma isoLG-protein levels increased at least 2.5-fold in response to inflammation.
Wujuan, Zhang, Robert G, Salomon
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Oxidized phospholipids and isoprostanes in atherosclerosis
Current Opinion in Lipidology, 1998Lipid oxidation has been shown to be a prominent feature of atherosclerosis. The presence of isoprostanes and other lipid oxidation products has been clearly demonstrated in lesions. Furthermore, antibodies to oxidized phospholipids have been identified in animal and human models.
J L, Witztum, J A, Berliner
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Bioactive phospholipid oxidation products
Free Radical Biology and Medicine, 2000Oxidation of phospholipids results in chain-shortened fragments and oxygenated derivatives of polyunsaturated sn-2 fatty acyl residues, generating a myriad of phospholipid products. Certain oxidation products of phosphatidylcholine bind to and activate the human receptor for PAF, and these PAF-like lipids are potent, selective inflammatory mediators ...
G K, Marathe +5 more
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Determination of pyrrolized phospholipids in oxidized phospholipid vesicles and lipoproteins
Analytical Biochemistry, 2004The Ehrlich reaction was optimized to determine pyrrolized phospholipids produced as a consequence of oxidative stress. The procedure consisted of the treatment of the modified phospholipids with p-(dimethylamino)benzaldehyde at a controlled acidity temperature and the spectrophotometric determination of adducts produced.
Francisco J, Hidalgo +2 more
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Mediation of Apoptosis by Oxidized Phospholipids
2008Free radical-mediated oxidation of (poly)unsaturated glycerophospholipids in membranes and lipoproteins leads to the formation of a plethora of products. Some of these oxidized phospholipids, especially the truncated forms, induce apoptosis depending on their chemical structure, concentration and cell type.
Fruhwirth, Gilbert O, Hermetter, Albin
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