Results 301 to 310 of about 63,046 (336)
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Oxidized phospholipids as novel mediators of neurodegeneration
Trends in Neurosciences, 2022Neurodegeneration drives the progression of many neurological diseases. Inflammation and oxidative stress occurring in the CNS promote lipid peroxidation, leading to the generation of oxidized phospholipids such as oxidized phosphatidylcholines (OxPCs).
Yifei Dong, V. Wee Yong
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[Oxidized phospholipids and atherosclerosis].
Sheng li xue bao : [Acta physiologica Sinica], 2021Phospholipids are important components of biomembrane and lipoproteins. Phospholipids can be oxidized by free radicals/nonradicals and enzymes to form oxidized phospholipids (OxPLs), which can lead to further generation of oxidation products with different biological activities.
Min, Zhao, Bo-Yan, Liu, Shu-Cun, Qin
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Inflammatory profile of oxidized phospholipids
Thrombosis and Haemostasis, 2007SummaryLipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells.
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Oxidation of Unsaturated Phospholipids: A Monolayer Study
Langmuir, 2020Lipid oxidation does strongly influence the self-organization of plasma membranes; the detailed influence is not yet clear. In this work, phospholipid monolayers at the air/water interface were used as model membranes. Oxidation was induced by the reactive oxygen species formed in a H2O2-enriched solution. The reaction was found to be diffusion-limited;
Florian Gellert +2 more
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Mass spectrometry analysis of oxidized phospholipids
Chemistry and Physics of Lipids, 2008The evidence that oxidized phospholipids play a role in signaling, apoptotic events and in age-related diseases is responsible for the increasing interest for the study of this subject. Phospholipid changes induced by oxidative reactions yield a huge number of structurally different oxidation products which difficult their isolation and ...
M Rosário M, Domingues +2 more
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The role of oxidized phospholipids in the development of disease
Molecular Aspects of Medicine, 2020Oxidized phospholipids (OxPLs), complex mixtures of phospholipid oxidation products generated during normal or pathological processes, are increasingly recognized to show bioactive effects on many cellular signalling pathways. There is a growing body of evidence showing that OxPLs play an important role in many diseases, so it is essential to define ...
Ji, Nie +3 more
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Oxidized phospholipids in Doxorubicin-induced cardiotoxicity
Chemico-Biological Interactions, 2019Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects leading to heart failure. The excessive oxidative stress caused by Dox results in the modification of a variety of cellular molecules, including phospholipids. In cardiomyocytes, Dox increases oxidation of a species of phospholipids, phosphatidylcholine, which has ...
Navid Koleini +5 more
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Chromatographic analysis of phospholipid and cholesterol oxidation
Talanta, 1984Capillary thin layer and gas chromatographic methods for analysis of the extent of oxidation in phosphatidyl choline/cholesterol samples are described. Examples of systems suitable for qualitative and quantitative analysis, based on use of unmodified samples or of their derivatives, are illustrated. A method for concurrent quantitative determination of
U J, Krull, M, Thompson, A, Arya
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Oxidized phospholipids as modulators of inflammation in atherosclerosis
Current Opinion in Lipidology, 2003This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions.Structural identification of new biologically active oxidized phospholipids and the finding that they can also be formed at inflammatory sites other than the atherosclerotic lesion have expanded the potential
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Oxidized phospholipid signaling in immune cells
Current Opinion in Pharmacology, 2012Oxidized phospholipids (oxPLs) that can be generated either enzymatically or non-enzymatically are fast becoming recognized as important signaling mediators of the immune system. Hundreds of structures exist, but only a small fraction have been studied in detail.
Christopher P, Thomas +1 more
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