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Determination of phospholipid oxidation in cultured cells
1999Publisher Summary This chapter discusses the use of high-performance liquid chromatography (HPLC) with postcolumn chemiluminescence detection for the measurement of lipid peroxidation in cultured cells. In this assay, extracted phospholipids are separated by HPLC over a silica column and individual lipid classes are detected by UV (ultra violet ...
G T, Shwaery +3 more
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Oxidized phospholipid signaling in immune cells
Current Opinion in Pharmacology, 2012Oxidized phospholipids (oxPLs) that can be generated either enzymatically or non-enzymatically are fast becoming recognized as important signaling mediators of the immune system. Hundreds of structures exist, but only a small fraction have been studied in detail.
Christopher P, Thomas +1 more
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Mass spectrometry analysis of oxidized phospholipids
Chemistry and Physics of Lipids, 2008The evidence that oxidized phospholipids play a role in signaling, apoptotic events and in age-related diseases is responsible for the increasing interest for the study of this subject. Phospholipid changes induced by oxidative reactions yield a huge number of structurally different oxidation products which difficult their isolation and ...
M Rosário M, Domingues +2 more
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Oxidized phospholipids as triggers of inflammation in atherosclerosis
Molecular Nutrition & Food Research, 2005Chronic inflammatory diseases including atherosclerosis are major causes of morbidity and mortality worldwide. However, the factors, which trigger processes that determine the outcome of an inflammatory response, are still poorly understood. Accumulating evidence suggests that certain lipid oxidation products, such as oxidized phospholipids (OxPL), may
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Oxidized phospholipids as modulators of inflammation in atherosclerosis
Current Opinion in Lipidology, 2003This review will summarize recent evidence demonstrating that biologically active phospholipid oxidation products modulate inflammatory reactions.Structural identification of new biologically active oxidized phospholipids and the finding that they can also be formed at inflammatory sites other than the atherosclerotic lesion have expanded the potential
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Isolevuglandins, Oxidatively Truncated Phospholipids, and Atherosclerosis
Annals of the New York Academy of Sciences, 2005Abstract: Isolevuglandins (isoLGs) and oxidatively truncated phospholipids are products of lipid peroxidation. Some of these, especially isoLGs and γ‐hydroxyalkenal analogues (e.g., the 5‐hydroxy‐8‐oxo‐6‐octenoic acid and 9‐hydroxy‐12‐oxo‐10‐dodecenoic acid esters of 2‐lysophosphatidylcholine, HOOA‐PC or HODA‐PC, respectively) of 4‐hydroxy‐2(E ...
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Protein modification and phospholipid oxidation
Free Radical Biology and Medicine, 2013Phospholipid oxidation can generate reactive and electrophilic products that are capable of modifying proteins, especially at cysteine, lysine and histidine residues. Such lipoxidation reactions are known to alter protein structure and function, both with gain of function and loss of activity effects.
Spickettn, C. M. +3 more
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The role of oxidized phospholipids in COVID-19-associated hypercoagulopathy.
European Review for Medical and Pharmacological Sciences, 2021S. Akpınar +5 more
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Lipoprotein(a) and Oxidized Phospholipids
Journal of the American College of Cardiology, 2023Daniel J. Rader, Archna Bajaj
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Oxidative hemolysis and erythrocyte phospholipids
Blood, 1978S K, Jain, P, Hochstein
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