Results 111 to 115 of about 1,722 (115)

Unveiling the potency of FDA-approved oxidopamine HBr for cervical cancer regulation and replication proteins

Medical Oncology
Cervical Cancer remains a women's health concern worldwide and ranks among the most prevalent cancers, particularly in developing countries. Many women are diagnosed with cervical cancer, with a substantial number succumbing to the disease even after the availability of vaccines and drugs.
Nawal Helmi, Abdullah Hamadi, Osama M. Al-Amer, Hassan A. Madkhali, Atif Abdulwahab A. Oyouni, Amany I. Alqosaibi, Jawaher Almulhim, Rashed Mohammed Alghamdi, Israa J. Hakeem, Misbahuddin M. Rafeeq   +9 more
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Multitargeted Docking, DFT-Based Optimisation, Pharmacokinetics, and MD Simulation Reveal 6-Oxidopamine HBr as a Multitargeted Inhibitor of Cervical Cancer Proteins

Current Medicinal Chemistry
Background: Cervical cancer originates in the cervix, the lower part of the uterus, and results from the uncontrolled growth of abnormal cervical cells, forming malignant tumours. It poses a major global health challenge, calling for innovative drug design strategies to enhance treatment outcomes.
Yossef Saeed, Alghamdi, Mutaib M, Mashraqi, Ohud, Alsalmi, Afaf Awwadh, Alharthi, Amal F, Gharib   +4 more
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Effect of chemical sympathectomy with oxidopamine on systemic blood flow in rats with acute pancreatitis.

Circulatory shock, 1986
In response to previous demonstrations that either surgical or chemical sympathectomy can ameliorate the severity of acute experimental pancreatitis, and suggestions that the benefits of sympathectomy are related to alterations in the absolute blood flow or the pattern of blood flow within the pancreas or splanchnic organs, we studied blood flow in ...
P E, Donahue, J L, Ferguson, P, Gama Filho, H S, Tsai, W, Law, H, Akimoto, L M, Nyhus   +6 more
openaire   +2 more sources

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Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999
To study effects of (-)-stepholidine (SPD) on the phosphorylation of a dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in the striatum of oxidopamine-lesioned rats.The amount of dephospho-DARPP-32 was measured by a back-phosphorylation assay.In the striatum of control rats, SPD per se had no effect on the phosphorylation of DARPP-32, but it ...
X, Guo, J, Liu, L L, Zou, J, Jin, B C, Wang, G Z, Jin   +5 more
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Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.

, 1998
Xiang Guo, Jian Liu, Linglong Zou, Jian Jin, Bocheng Wang, Guo-Zhang Jin   +5 more
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