Results 111 to 114 of about 1,706 (114)

Multitargeted Docking, DFT-Based Optimisation, Pharmacokinetics, and MD Simulation Reveal 6-Oxidopamine HBr as a Multitargeted Inhibitor of Cervical Cancer Proteins

open access: closedCurrent Medicinal Chemistry
Background: Cervical cancer originates in the cervix, the lower part of the uterus, and results from the uncontrolled growth of abnormal cervical cells, forming malignant tumours. It poses a major global health challenge, calling for innovative drug design strategies to enhance treatment outcomes.
Yossef Saeed Alghamdi   +4 more
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Effect of chemical sympathectomy with oxidopamine on systemic blood flow in rats with acute pancreatitis.

open access: closedCirculatory shock, 1986
In response to previous demonstrations that either surgical or chemical sympathectomy can ameliorate the severity of acute experimental pancreatitis, and suggestions that the benefits of sympathectomy are related to alterations in the absolute blood flow or the pattern of blood flow within the pancreas or splanchnic organs, we studied blood flow in ...
Donahue Pe   +6 more
openalex   +2 more sources
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Enhancement of (-)-stepholidine on protein phosphorylation of a dopamine- and cAMP-regulated phosphoprotein in denervated striatum of oxidopamine-lesioned rats.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1999
To study effects of (-)-stepholidine (SPD) on the phosphorylation of a dopamine- and cAMP-regulated phosphoprotein (DARPP-32) in the striatum of oxidopamine-lesioned rats.The amount of dephospho-DARPP-32 was measured by a back-phosphorylation assay.In the striatum of control rats, SPD per se had no effect on the phosphorylation of DARPP-32, but it ...
X, Guo   +5 more
openaire   +1 more source

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