Results 31 to 40 of about 1,271 (136)

Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis [PDF]

, 2012
Tuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking pathway to escape clearance from infected macrophages.
A Alexander, A Hemphill, A Koul, A Mercalli, A Stockis, A Stockis, A Yamamoto, AD Balgi, AL Hestvik, AM Moyer, AO Barry, Aruna D. Balgi, AT Dinkova-Kostova, AT Dinkova-Kostova, C White, CB Bui, CC Thoreen, CC Thoreen, CH Jung, CS Hirsch, D Biswas, D Curman, D Glick, D Siegel, D Wong, DG Russell, DJ Klionsky, DM Musher, DR Alessi, DS Horner, E Jacinto, G Asher, G Asher, H Bach, H Ham, H Zhang, HH Zhang, Hilary J. Anderson, HJ Prochaska, I Tanida, I Vergne, J Chao, J Huang, J Huang, J Muller, J Muller, JA Armstrong, JD McKinney, JF Rossignol, JF Rossignol, JF Rossignol, JF Rossignol, JF Rossignol, JW Fahey, K Degenhardt, Karen K. Y. Lam, KK Huynh, LJ Xue, LM Fox, LP de Carvalho, M Degtyarev, M Kathania, M Lateef, M Ponpuak, MA Espinal, Matt Nodwell, MG Gutierrez, Michel Roberge, P Tsvetkov, PE Burnett, PS Hoffman, RA Floto, RA Floto, RA Fratti, Raymond J. Andersen, Roberto Forestieri, S Alonso, S Pankiv, S Ramon-Garcia, S Sturgill-Koszycki, Sarah Vollett, T Shintani, T Yoshimori, TE Ballard, V Deretic, V Deretic, VA Rao, Vojo Deretic, WH Habig, WW Yew, Xingji Zheng, Yossef Av-Gay, Z Yang   +92 more
core   +4 more sources

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

Bioinorganic Chemistry [PDF]

, 1994
This book covers material that could be included in a one-quarter or one-semester course in bioinorganic chemistry for graduate students and advanced undergraduate students in chemistry or biochemistry.
Bertini, Ivano, Gray, Harry B., Lippard, Stephen J., Valentine, Joan Selverstone   +3 more
core   +1 more source

Insights on Regioselective Synthesis of Fused Thiazoles: Density Functional Theory Calculations, Local Reactivity Indices, and Molecular Electrostatic Potential Analysis

ChemistryOpen, Volume 14, Issue 12, December 2025.
A regioselective synthesis of fused thiazoles was achieved via aza‐Michael cyclization of thiazolidinone derivatives with hydrazines or heteroaryl amines. Density functional theory, local reactivity indices, and molecular electrostatic potential mapping are used to explain selectivity.
Ghaferah H. Al‐Hazmi, Jehan Y. Al‐Humaidi, Sayed M. Riyadh, Mohamed S. M. Ahmed, Magdi E. A. Zaki, Awatif H. Alruwaili, Khaled A. Alanazi, Rajeh H. Almutairi, Sobhi M. Gomha   +8 more
wiley   +1 more source

Mechanistic Studies on D-arginine Dehydrogenase and Functional Annotation of a Novel NADH:quinone Oxidoreductase (PA1024) [PDF]

, 2018
Pseudomonas aeruginosa D-arginine dehydrogenase (PaDADH) is an FAD-dependent enzyme that catalyzes the oxidative deamination of D-arginine to generate the corresponding α-keto acid and ammonia.
Ball, Jacob A
core   +3 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Movement Mechanisms Harness Lévy Flight for Energy‐Efficient Wastewater Treatment in Microalgae–Bacteria Systems

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Here, our novel model that integrates metabolism with motility dynamics reveals that microalgae shift bacterial movement toward Lévy flight patterns, enhancing encounter rates and self‐aggregation. This microecological manipulation reduces energy costs, strengthens functions such as pollutant removal and system stability.
Luyu Zhang, Yu Tian, Lipin Li, Wei Zhan, Huihang Sun, Nanqi Ren, Zhurui Tang, Huu Hao Ngo   +7 more
wiley   +1 more source

Liver molecular networks associated with drinking behavior in nonhuman primates

Alcohol, Clinical and Experimental Research, Volume 49, Issue 11, Page 2470-2484, November 2025.
We identified hepatic molecular networks that differed between light drinkers (LD) and very heavy drinkers (VHD) before they were exposed to alcohol, as well as epigenetic differences between LD and VHD in response to the same amount of alcohol.
Laura A. Cox, James B. Daunais, Timothy D. Howard, Ge Li, Sobha Puppala, Jeannie Chan, Zeeshan Hamid, Samer Gawrieh, Sun Mi Lee, Betsy Ferguson, Kathleen A. Grant, Michael Olivier   +11 more
wiley   +1 more source

Micro‐Environment Programmable Quinoline COFs for High‐Performance Photocatalytic H2O2 Generation and Benzylamine Coupling

Advanced Science, Volume 12, Issue 33, September 4, 2025.
A series of bio‐inspired quinoline‐based covalent organic frameworks (COFs) with varying substituents (‐R) are synthesized via multi‐component reactions. These substituents demonstrated a pronounced structure‐property relationship between their electronic effects (Hammett parameter, σp) and the photocatalytic H₂O₂ production rate, as well as the ...
Mengchao Guo, Chao He, Zihe Wu, Yu Tian, Jiani Yang, Yujie Wang, Hao Wu, Jin Yang, Min Xu, Weichao Xue, Chong Cheng, Shuang Li, Changsheng Zhao   +12 more
wiley   +1 more source

Rationally Designed InhA Inhibitors: A Comparative Anti‐Tubercular Activity Study of Sulfonate Esters of Isoniazid Hydrazones and Their Structurally Flexible Benzyl Analogues

Chemical Biology &Drug Design, Volume 106, Issue 3, September 2025.
A comparative anti‐tubercular evaluation of sulfonate esters of isoniazid hydrazones and their structurally flexible benzyl analogues disclosed several potent compounds against Mycobacterium tuberculosis with the representative compound displaying an MIC of 0.078 μg/mL.
Mukanda Gedeon Kadima, Sahil Mishra, Gobind Kumar, Pule Seboletswe, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Rajshekhar Karpoormath, Parvesh Singh   +8 more
wiley   +1 more source