Results 41 to 50 of about 1,271 (136)

Computational Design, Synthesis, and Biological Assessment of Some Pyrrolo[3,4‐c]Pyrroles Targeting Mycobacterium Tuberculosis

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya, Rajamanikandan Sundararaj, Kailasam Saravana Mani, Krishnakumar Balu, Mani Durai, Perwez Alam, Priya SD, Mathivanan Durai, Young Ho Ahn   +8 more
wiley   +1 more source

Lycium‐Barbarum Polysaccharide‐Loaded Dual‐Crosslinked Rigid Hydrogel Enhances Bone Healing in Diabetic Bone Defects by Scavenging Reactive Oxygen Species

Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.
A novel hydrogel (HLBP) incorporating natural polysaccharides from goji berries is developed to enhance diabetic bone defect healing. The hydrogel efficiently scavenges ROS, improves osteogenic differentiation, and promotes in vivo bone regeneration. This strategy offers a biocompatible and localized approach, overcoming the challenges of traditional ...
Wenjie Zhong, Wenao Liao, Lingcong Xu, Niezhenghao He, Ke Xu, Caiyuan Liu, Fei Wang, Wei Zhang, Jiang Hu, Haowen Cui   +9 more
wiley   +1 more source

Biotransformations using lipase enzymes in organic solvents [PDF]

, 1993
Enzymatic transformations in organic solvents have received increasing attention over the past 10 years and lipases have become by far the most popular enzymes in this area.The initial aim of the research was to assess the effect of small modifications ...
Sanvoisin, Jonathan
core  

3‐D Sustained‐Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Schematic representation of mechanisms by which the 3‐D sustained‐release culture carrier prevents accumulation of ROS by continuously releasing C‐176@PDA‐NPs and inhibiting the cGAS‐STING activated by sudden hypoxia, thereby preventing ferroptosis and promoting differentiation in SSCs and ultimately attenuating IVDD progression.
Liwen Luo, Shiyu Zhang, Junfeng Gong, Ji Zhang, Peng Xie, Jun Yin, MengJie Zhang, Cong Zhang, Hong Chen, Yao Liu, Bing Ni, Changqing Li, Zhiqiang Tian   +12 more
wiley   +1 more source

Bio‐inspired Catalyst‐Modified Photocathode for Bias‐Free Photoelectrochemical NADH Regeneration

Advanced Science, Volume 12, Issue 8, February 24, 2025.
Inspired by the structure and function of the thylakoid membrane and electron transport mediator function of Ferredoxin, a catalyst‐immobilized photocathode is constructed by self‐assembly of the aliphatic chain substituted [Rh(Cp*)(bpy)] molecules (Rh‐vi2+) and aliphatic chain decorated polythiophene semiconductors (PTTH), which can be coupled with a ...
Ziqi Zhao, Yizhou Wu, Chang Liu, Yingzheng Li, Chen Gong, Hongxia Ning, Peili Zhang, Fei Li, Licheng Sun, Fusheng Li   +9 more
wiley   +1 more source

Enzymatic and Enzyme‐Free Electrochemical Lactate Sensors: A Review of the Recent Developments

Electrochemical Science Advances, Volume 5, Issue 1, February 2025.
ABSTRACT Lactate is a useful analytical indicator in various fields. The lactate monitoring benefits from evaluating the body's condition, as excessive muscle use or fatigue can result in injury. Further, it is useful for alerting to emergencies like haemorrhage, hypoxia, respiratory distress, and sepsis.
Heru Agung Saputra, Md Mobarok Karim
wiley   +1 more source

Star‐Like Polypeptides as Simplified Analogues of Horseradish Peroxidase (HRP) Metalloenzymes

Macromolecular Bioscience, Volume 24, Issue 10, October 2024.
Peroxidases like HRP are powerful biocatalysts for oxidation reactions. Inspired by HRP, star‐shaped polypeptide analogues are synthesized via a grafting‐from approach, ring‐opening polymerization, and manganese porphyrins. These analogues exhibit enhanced resistance to denaturation and catalytic activity in oxidation reactions with H2O2.
Antoine Tronnet, Pedro Salas‐Ambrosio, Rosa Roman, Lourdes Monica Bravo‐Anaya, Marcela Ayala, Colin Bonduelle   +5 more
wiley   +1 more source

Biomimetic models for redox enzyme systems [PDF]

, 2009
Supramolecular chemistry involves the study of noncovalent interactions that take place between molecules. A supramolecule or host-guest complex is formed when a noncovalent binding or complexation event occurs between two such molecules. Hydrogen bonds,
Kennedy, Andrew A.
core   +1 more source

The radical impact of oxygen on prokaryotic evolution—enzyme inhibition first, uninhibited essential biosyntheses second, aerobic respiration third

FEBS Letters, Volume 598, Issue 14, Page 1692-1714, July 2024.
Traditional views of oxygen's role in evolution focus on improved energy yield in heterotrophic pathways. Before respiratory terminal oxidases arose, however, oxygen potently inhibited anaerobic growth, often by degrading FeS clusters. Several pathways for essential cofactors include enzymes with FeS clusters, selecting for alternative, oxygen‐tolerant
Natalia Mrnjavac, Falk S. P. Nagies, Jessica L. E. Wimmer, Nils Kapust, Michael R. Knopp, Katharina Trost, Luca Modjewski, Nico Bremer, Marek Mentel, Mauro Degli Esposti, Itzhak Mizrahi, John F. Allen, William F. Martin   +12 more
wiley   +1 more source

The extracellular peroxygenase of the agaric fungus Agrocybe aegerita: catalytic properties and physiological background with particular emphasis on ether cleavage [PDF]

, 2010
Litter-decay fungi have recently been shown to secrete heme-thiolate peroxygenases that oxidize various organic chemicals, but little is known about the physiological role or the mechanism of these enzymes. The aromatic peroxygenase of Agrocybe aegerita (
Kinne, Matthias
core   +1 more source