Results 21 to 30 of about 1,315 (98)

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

open access: yesThe FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova   +5 more
wiley   +1 more source

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

open access: yesJournal of Fish Biology, EarlyView.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne   +4 more
wiley   +1 more source

MT@SiO2 Enhances MEK5‐MAPK6‐NAC32 Mediated Salicylic Acid Synthesis Which Increases Resistance to Glomerella Leaf Spot in Apple

open access: yesPlant Biotechnology Journal, EarlyView.
ABSTRACT Glomerella leaf spot (GLS), a fungal disease caused by Colletotrichum fructicola, is a major destructive disease of apples but research on control measures is limited. Melatonin (MT) is a phytohormone‐like compound that affects plant growth and stress response but is prone to light‐induced degradation, resulting in low stability and efficacy ...
Yong Zhang   +7 more
wiley   +1 more source

Engineered surface strategies to manage dental implant‐related infections

open access: yesPeriodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza   +7 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma   +12 more
wiley   +1 more source

Rieske Iron–Sulfur Cluster Proteins From an Anaerobic Ammonium Oxidizer Suggest Unusual Energetics in Their Parent Rieske/Cytochrome b Complexes

open access: yesProteins: Structure, Function, and Bioinformatics, Volume 94, Issue 4, Page 905-920, April 2026.
ABSTRACT Anaerobic ammonium‐oxidizing (anammox) bacteria employ a unique, hydrazine‐based pathway to obtain energy from nitrite and ammonium. These organisms possess distinct Rieske/cytochrome b complexes whose precise role in anammox metabolism remains unclear, but which have been proposed to include the generation of NAD(P)H.
David Hauser   +4 more
wiley   +1 more source

Effects of Cannabidiol on TAFAZZIN‐Deficient B‐Lymphoblastoid Cells

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Deficiency of the cardiolipin remodeling enzyme TAFAZZIN causes Barth syndrome (BTHS), resulting in cardiolipin loss, monolysocardiolipin (MLCL) accumulation, and electron transport chain (ETC) abnormalities in B‐lymphoblastoid cells. Effects of the non‐psychotropic phytocannabinoid cannabidiol (CBD) were examined on B‐lymphoblastoid cells from ...
John Z. Chan   +10 more
wiley   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

open access: yesAdvanced Science, Volume 13, Issue 14, 9 March 2026.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge   +21 more
wiley   +1 more source

Integrated bioconversion of starchy and hemicellulosic fractions of macauba oil presscake into ethanol by nonconventional yeasts

open access: yesBiofuels, Bioproducts and Biorefining, Volume 20, Issue 2, Page 779-792, March/April 2026.
Abstract Co‐fermentation of hexoses and pentoses from plant biomass to ethanol is a strategy to increase ethanol production from lignocellulosic materials and add value to residues from agroindustrial chains. The macauba (Acrocomia aculeata) is an oleaginous palm‐tree species considered to contribute to development in some regions of Brazil.
Filipe Soares de Freitas   +7 more
wiley   +1 more source

Broadening the Workflow for Synchrotron‐Based X‐Ray Fluorescence and X‐Ray Absorption Spectroscopy Imaging of Low‐Abundance Cellular Metals

open access: yesChemistry–Methods, Volume 6, Issue 3, March 2026.
We present an accessible plunge‐freezing and freeze‐drying workflow for preparing adherent mammalian cells for synchrotron‐based nanofocused X‐ray fluorescence (XRF) microscopy and X‐ray absorption spectroscopy (XAS), enabling sub‐micron mapping of metal distribution and chemical speciation.
Joaquin Tamargo‐Azpilicueta   +8 more
wiley   +1 more source

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