Results 11 to 20 of about 893 (117)

Identification of oxidosqualene cyclases associated with saponin biosynthesis from Astragalus membranaceus reveals a conserved motif important for catalytic function

Journal of Advanced Research, 2023
Introduction: Triterpenoids and saponins have a broad range of pharmacological activities. Unlike most legumes which contain mainly oleanane-type scaffold, Astragalus membranaceus contains not only oleanane-type but also cycloartane-type saponins, for ...
Kuan Chen, Meng Zhang, Lulu Xu, Yang Yi, Linlin Wang, Haotian Wang, Zilong Wang, Jiangtao Xing, Pi Li, Xiaohui Zhang, Xiaomeng Shi, Min Ye, Anne Osbourn, Xue Qiao   +13 more
doaj   +1 more source

Overexpression of TwSQS, TwSE, and TwOSC Regulates Celastrol Accumulation in Cambial Meristematic Cells and Dedifferentiated Cells

Frontiers in Plant Science, 2022
Squalene synthase (SQS), squalene epoxidase (SE), and oxidosqualene cyclase (OSC) are encoding enzymes in downstream biosynthetic pathway of triterpenoid in plants, but the relationship between three genes and celastrol accumulation in Tripterygium ...
Yadi Song, Yadi Song, Jiawei Zhou, Yifeng Zhang, Yujun Zhao, Xiujuan Wang, Tianyuan Hu, Yuru Tong, Luqi Huang, Wei Gao, Wei Gao   +10 more
doaj   +1 more source

Evaluation of bacterial strains for the induction of plant biochemicals, nutritional contents and isozymes in barley [PDF]

, 2017
The controlled placement of gold nanoparticles (AuNPs) in poly­(styrene-b-isoprene-b-styrene) [SIS] triblock copolymer thin films was achieved by tuning the surface chemistry of the AuNPs.
Anjum, Tehmina, Ishaq Khan, Dr Rizwan, Naughton, Declan, Qadir, Abdul, Yousaf, Ali, Yousaf, Anam   +5 more
core   +6 more sources

Impact of steroid biosynthesis on the aerobic adaptation of eukaryotes. [PDF]

Geobiology
Abstract Steroids are indispensable components of the eukaryotic cellular membrane and the acquisition of steroid biosynthesis was a key factor that enabled the evolution of eukaryotes. The polycyclic carbon structures of steroids can be preserved in sedimentary rocks as chemical fossils for billions of years and thus provide invaluable clues to trace ...
Hoshino Y, Gaucher EA.
europepmc   +2 more sources

Lactobacillus acidophilus K301 Inhibits Atherogenesis via Induction of 24 (S), 25-Epoxycholesterol-Mediated ABCA1 and ABCG1 Production and Cholesterol Efflux in Macrophages. [PDF]

PLoS ONE, 2016
Lactobacillus acidophilus species are well-known probiotics with the beneficial activity of regulating cholesterol levels. In this study, we showed that L. acidophilus K301 reduced the level of cholesterol through reverse transport in macrophages.
Yi-Fan Hong, Hangeun Kim, Hye Sun Kim, Woo Jung Park, Joo-Yun Kim, Dae Kyun Chung   +5 more
doaj   +1 more source

Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage. [PDF]

New Phytol
Summary Plant lipid droplets (LDs) and their associated proteins have numerous subcellular and physiological functions. While considerable progress has been made for LDs in many tissues, the function and composition of LDs in roots remain largely unexplored.
Scholz P, Dabisch J, Vilchez AC, Clews AC, Niemeyer PW, Lim MSS, Sun S, Hembach L, Naganawa M, Dreier F, Blersch KF, Preuß LM, Bonin M, Lesch E, Iwai Y, Shimada TL, Eirich J, Finkemeier I, Gutbrod K, Dörmann P, Wang Y, Mullen RT, Ischebeck T.   +22 more
europepmc   +2 more sources

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial [PDF]

, 2021
Phenotypic screening identified a benzothiophene compound with activity against Leishmania donovani, the causative agent of visceral leishmaniasis. Using multiple orthogonal approaches, oxidosqualene cyclase (OSC), a key enzyme of sterol biosynthesis ...
Bello, Davide, Carvalho, Sandra, Chemi, Giulia, Corpas-Lopez, Victoriano, Fairlamb, Alan H., Ferguson, Michael A. J., Gilbert, Ian H., Martin, Julio, Moynihan, Eoin, Patterson, Stephen, S. Guther, Maria Lucia, S. Paradela, Luciana, Wall, Richard J., Wyllie, Susan, Zuccotto, Fabio   +14 more
core   +3 more sources

Evolution‐guided multiomics provide insights into the strengthening of bioactive flavone biosynthesis in medicinal pummelo

Plant Biotechnology Journal, Volume 21, Issue 8, Page 1577-1589, August 2023., 2023
Summary Pummelo (Citrus maxima or Citrus grandis) is a basic species and an important type for breeding in Citrus. Pummelo is used not only for fresh consumption but also for medicinal purposes. However, the molecular basis of medicinal traits is unclear.
Weikang Zheng, Wang Zhang, Dahui Liu, Minqiang Yin, Xia Wang, Shouchuang Wang, Shuangqian Shen, Shengjun Liu, Yue Huang, Xinxin Li, Qian Zhao, Lu Yan, Yuantao Xu, Shiqi Yu, Bin Hu, Tao Yuan, Zhinan Mei, Lanping Guo, Jie Luo, Xiuxin Deng, Qiang Xu, Luqi Huang, Zhaocheng Ma   +22 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high-definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next-generation galeterone analog VNPP433-3β in castration-resistant prostate cancer. [PDF]

Mol Oncol
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Thankan RS, Thomas E, Weldemariam MM, Purushottamachar P, Huang W, Kane MA, Zhang Y, Ambulos N, Wang BD, Weber D, Njar VCO.   +10 more
europepmc   +2 more sources

Spatiotemporal transcriptomics and metabolic profiling provide insights into gene regulatory networks during lentil seed development

The Plant Journal, Volume 115, Issue 1, Page 253-274, July 2023., 2023
SUMMARY Lentil (Lens culinaris Medik.) is a nutritious legume with seeds rich in protein, minerals and an array of diverse specialized metabolites. The formation of a seed requires regulation and tight coordination of developmental programs to form the embryo, endosperm and seed coat compartments, which determines the structure and composition of ...
Bianyun Yu, Peng Gao, Jingpu Song, Hui Yang, Li Qin, Xiaoyu Yu, Halim Song, Justin Coulson, Yasmina Bekkaoui, Leonid Akhov, Xiumei Han, Dustin Cram, Yangdou Wei, L. Irina Zaharia, Jitao Zou, David Konkin, Teagen D. Quilichini, Pierre Fobert, Nii Patterson, Raju Datla, Daoquan Xiang   +20 more
wiley   +1 more source