Results 21 to 30 of about 893 (117)

Meliaceae genomes provide insights into wood development and limonoids biosynthesis

open access: yesPlant Biotechnology Journal, Volume 21, Issue 3, Page 574-590, March 2023., 2023
The chromosome‐level genome of Azadirachta indica and Melia azedarach were provided. Meliaceae should be classified into two subfamilies: Cedreloideae and Melioideae. Cellulose/hemicellulose biosynthesis‐related genes expanded notably in woody Toona sinensis. Expanded special oxidosqualene cyclase catalogues help diversify Sapindales skeletons.
Gaofeng Cui   +8 more
wiley   +1 more source

Comparative transcriptomic analysis of genes in the triterpene saponin biosynthesis pathway in leaves and roots of Ardisia kteniophylla A. DC., a plant used in traditional Chinese medicine

open access: yesEcology and Evolution, Volume 12, Issue 5, May 2022., 2022
We investigated the genetic basis for the production of triterpenoid saponins in the medicinal plant, Ardisia kteniophylla, using transcriptome sequences and qRT‐PCR. We found that genes involved in late stages of triterpenoid saponin biosynthesis are upregulated in roots, which are traditionally regarded as the medicinal organ of the plant, compared ...
Yuyang Lei   +6 more
wiley   +1 more source

The Oxidosqualene Cyclase from the Oomycete Saprolegnia parasitica Synthesizes Lanosterol as a Single Product [PDF]

open access: yes, 2016
The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol (LA) or cycloartenol (CA). This is catalyzed by an oxidosqualene cyclase (OSC). LA and CA are subsequently converted into various sterols by
Lauren S. McKee   +3 more
core   +2 more sources

Multi-tissue transcriptome analysis using hybrid-sequencing reveals potential genes and biological pathways associated with azadirachtin A biosynthesis in neem (azadirachta indica)

open access: yesBMC Genomics, 2020
Background Azadirachtin A is a triterpenoid from neem tree exhibiting excellent activities against over 600 insect species in agriculture. The production of azadirachtin A depends on extraction from neem tissues, which is not an eco-friendly and ...
Huiyan Wang, Ning Wang, Yixin Huo
doaj   +1 more source

New Trends and Future Opportunities in the Enzymatic Formation of C−C, C−N, and C−O bonds

open access: yesChemBioChem, Volume 23, Issue 6, March 18, 2022., 2022
Recent research on the biocatalytic formation of new C−C, C−N, and C−O is surveyed in this review to provide an overview of the current state‐of‐the‐art in the field as well as future perspectives. Abstract Organic chemistry provides society with fundamental products we use daily.
Jack J. Sangster   +3 more
wiley   +1 more source

A co-opted steroid synthesis gene, maintained in sorghum but not maize, is associated with a divergence in leaf wax chemistry [PDF]

open access: yes, 2021
Virtually all land plants are coated in a cuticle, a waxy polyester that prevents nonstomatal water loss and is important for heat and drought tolerance. Here, we describe a likely genetic basis for a divergence in cuticular wax chemistry between Sorghum
Busta, Lucas   +4 more
core   +5 more sources

Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor

open access: yesJournal of Lipid Research, 2004
Induction of cataracts in experimental animals is a common toxic feature of oxidosqualene cyclase (OSC) inhibitors. U18666A has been shown to produce irreversible lens damage within a few weeks of treatment.
Richard J. Cenedella   +7 more
doaj   +1 more source

The TriForC database : a comprehensive up-to-date resource of plant triterpene biosynthesis [PDF]

open access: yes, 2018
Triterpenes constitute a large and important class of plant natural products with diverse structures and functions. Their biological roles range from membrane structural components over plant hormones to specialized plant defence compounds.
Bak, Soren   +8 more
core   +2 more sources

Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo

open access: yesJournal of Lipid Research, 1997
BIBB 515 (1-(4-chlorobenzoyl)-4-((4-(2-oxazolin-2-yl) benzylidene))piperidine) is a potent and selective inhibitor of 2,3-oxidosqualene cyclase (OSC) [EC 5.4.99.7].
B Eisele   +4 more
doaj   +1 more source

Engineering The Unicellular Alga Phaeodactylum tricornutum For High-Value Plant Triterpenoid Production [PDF]

open access: yes, 2018
Plant triterpenoids constitute a diverse class of organic compounds that play a major role in development, plant defense and environmental interaction. Several triterpenes have demonstrated potential as pharmaceuticals.
Allen, MJ   +8 more
core   +2 more sources

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