Results 41 to 50 of about 893 (117)

Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum

Journal of Phycology, Volume 61, Issue 3, Page 512-528, June 2025.
Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner, Luca Morelli, Payal Patwari, Michele Fabris   +3 more
wiley   +1 more source

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source

A single oxidosqualene cyclase produces the seco-triterpenoid α-onocerin [PDF]

, 2017
8,14-seco-Triterpenoids are characterized by their unusual open C-ring. Their distribution in nature is rare and scattered in taxonomically unrelated plants. The 8,14-seco-triterpenoid alpha-onocerin is only known from the evolutionarily distant clubmoss
Almeida, Aldo, Appendino, Giovanni, Bak, Søren, Bassard, Jean-Etienne, Dong, Lemeng, Goossens, Alain, Khakimov, Bekzod, Lota, Frederic, Moses, Tessa   +8 more
core   +4 more sources

Navigating the challenges of engineering composite specialized metabolite pathways in plants

The Plant Journal, Volume 121, Issue 6, March 2025.
SUMMARY Plants are a valuable source of diverse specialized metabolites with numerous applications. However, these compounds are often produced in limited quantities, particularly under unfavorable ecological conditions. To achieve sufficient levels of target metabolites, alternative strategies such as pathway engineering in heterologous systems like ...
Sachin A. Gharat, Vaijayanti A. Tamhane, Ashok P. Giri, Asaph Aharoni   +3 more
wiley   +1 more source

The cholesterol biosynthesis enzyme oxidosqualene cyclase is a new target to impair tumour angiogenesis and metastasis dissemination [PDF]

, 2015
Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of cholesterol biosynthesis, oxidosqualene cyclase (OSC), in regulating tumour angiogenesis and ...
Balliano, Gianni, Bussolino, Federico, Claudia, Meda, Di Nicolantonio, Federica, Federica, Maione, Giraudo, Enrico, Oliaro Bosso, Simonetta, Viola, Franca Cecilia   +7 more
core   +1 more source

Genome‐Wide Association Studies of Polysaccharides, Collagen, and Saponin Traits in the Sea Cucumber Apostichopus japonicus

Aquaculture Research, Volume 2025, Issue 1, 2025.
Apostichopus japonicus is a commercially important marine species known for its high nutritional value and a range of bioactive compounds, including polysaccharides, collagen, and saponins. In this study, a genome‐wide association study (GWAS) was carried out on 143 A. japonicus individuals.
Yongjie Wang, Xianglei Zhang, Shufeng Li, Ye Tian, Weiyan Li, Qi Ye, Fenglin Tian, Haoran Xiao, Junhui Wang, Wanrong Tian, Hao Wang, Yangqing Chang, Chong Zhao, Luo Wang, Lingshu Han, Jun Ding   +15 more
wiley   +1 more source

Identification of early quassinoid biosynthesis in the invasive tree of heaven (Ailanthus altissima) confirms evolutionary origin from protolimonoids [PDF]

, 2022
The tree of heaven, Ailanthus altissima (MILL.) SWINGLE, is a globally invasive plant known to secrete allelopathic metabolites called quassinoids. Quassinoids are highly modified triterpenoids.
Biedermann, Dave, Chuang, Ling, Franke, Jakob, Liu, Shenyu   +3 more
core   +2 more sources

CmBr confers fruit bitterness under CPPU treatment in melon

Plant Biotechnology Journal, Volume 22, Issue 10, Page 2724-2737, October 2024.
Summary Many biotic or abiotic factors such as CPPU (N‐(2‐chloro‐pyridin‐4‐yl)‐N′‐phenylurea), a growth regulator of numerous crops, can induce bitterness in cucurbits. In melon, cucurbitacin B is the major compound leading to bitterness. However, the molecular mechanism underlying CuB biosynthesis in response to different conditions remains unclear ...
Mingyan Wang, Naiyu Jiang, Yuanchao Xu, Xinxiu Chen, Cui Wang, Chuangjiang Wang, Shiqi Wang, Kuipeng Xu, Sen Chai, Qing Yu, Zhonghua Zhang, Huimin Zhang   +11 more
wiley   +1 more source

Oxysterols and Their Cellular Effectors [PDF]

, 2012
Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain
Béaslas, Olivier, Nissilä, Eija, Olkkonen, Vesa M.   +2 more
core   +3 more sources

Genomics of Terpene Biosynthesis in Dictyoceratid Sponges (Porifera) – What Do We (Not) Know?

Chemistry &Biodiversity, Volume 21, Issue 9, September 2024.
Abstract Sponges are recognized as promising sources for novel bioactive metabolites. Among them are terpenoid metabolites that constitute key biochemical defense mechanisms in several sponge taxa. Despite their significance, the genetic basis for terpenoid biosynthesis in sponges remains poorly understood.
Adrian Galitz, Sergio Vargas, Olivier P. Thomas, Maggie M. Reddy, Gert Wörheide, Dirk Erpenbeck   +5 more
wiley   +1 more source