Lateral transfer of tetrahymanol-synthesizing genes has allowed multiple diverse eukaryote lineages to independently adapt to environments without oxygen [PDF]
, 2012 Sterols are key components of eukaryotic cellular membranes that are synthesized by multi-enzyme pathways that require molecular oxygen. Because prokaryotes fundamentally lack sterols, it is unclear how the vast diversity of bacterivorous eukaryotes that
AKINORI, YABUKI +13 more
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Ecology and Evolution, Volume 14, Issue 7, July 2024.The transcriptional profiles of specialized metabolism shown here reveal complex genetic control of plant metabolism and contribute to understanding the molecular basis of adaptations and the physiological variation of significant ecological traits. Abstract Differential expression of genes is key to mediating developmental and stress‐related plant ...
Eunice Kariñho Betancourt +5 more
wiley +1 more source
Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication [PDF]
, 2010 SREBP-2, oxidosqualene cyclase (OSC) or lanosterol demethylase were identified as novel sterol pathway-associated targets that, when probed with chemical agents, can inhibit hepatitis C virus (HCV) replication.Using a combination chemical genetics ...
Alexis A Borisy +18 more
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Overexpression of squalene-hopene cyclase by the pET vector in Escherichia coli and first identification of tryptophan and aspartic acid residues inside the QW motif as active sites. [PDF]
, 1998 An overexpression system for squalene-hopene cyclase (SHC) was constructed by using the pET3a vector, which is responsible for high expression with help from the strong T7 promoter when incorporated into E. coli BL21 (DE3).
4386 +5 more
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Cholesterol metabolism: physiological regulation and diseases
MedComm, Volume 5, Issue 2, February 2024.At present, increasing evidence suggests that abnormal cholesterol metabolism is closely related to various systemic diseases, including cardiovascular disease, tumors, neurological conditions immune system disorders, and eye diseases. Cholesterol overload caused by abnormal cholesterol metabolism can induce elevated oxidative stress, heightened ...
Jiarui Guo +8 more
wiley +1 more source
Aquaculture Research, Volume 2024, Issue 1, 2024.Apostichopus japonicus is one of the few animals that can synthesize saponins. Present understanding of saponin biosynthesis is often limited to genome analysis, leaving the precise mechanism still unclear. This study examined the potential role of a gene annotated as farnesyl pyrophosphate synthase (FPS) in saponin biosynthesis of A. japonicus.
Pingzhe Jiang +12 more
wiley +1 more source
Oxidosqualene cyclases involved in the biosynthesis of triterpenoids in Quercus suber cork [PDF]
, 2020 Cork is a water-impermeable, suberin-based material harboring lignin, (hemi)cellulose, and extractable small molecules (primarily triterpenoids). Extractables strongly influence the properties of suberin-based materials.
Busta, Lucas +6 more
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Έκφραση της συνθάσης της λουπεόλης σε αναπτυσσόμενα φυτά Lotus japonicus [PDF]
, 2010 Σημείωση: διατίθεται συμπληρωματικό υλικό σε ξεχωριστό ...
Πλέσσα, Αλεξάνδρα
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Catalytic function of the residues of phenylalanine and tyrosine conserved in squalene-hopene cyclases. [PDF]
, 2001 Site-directed mutagenesis experiments on all the conserved residues of Phe and Tyr in all the known squalene-hopene cyclases (SHCs) were carried out to identify the active site residues of thermophilic Alicyclobacillus acidocaldarius SHC.
4346 +3 more
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マングローブにおけるテルペノイド生合成に関する研究 [PDF]
, 2008 鹿児島大学博士(農学)Doctor of Philosophy in Agricultural Science学位論文の要旨, 学位論文本文連合農学研究科博士論文(農学) ; 学位取得日: 平成20年3月14日doctoral ...
126487 +2 more
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