Results 91 to 100 of about 1,209,115 (296)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Autoxidation of lipids in parchment [PDF]
, 2009 Historic parchment is a macromolecular material, which is complex due to its natural origin, inhomogeneity of the skin structure, unknown environmental history and potential localised degradation.
Cassar, M. +5 more
core
Oxygen-vacancy driven electron localization and itinerancy in rutile-based TiO$_2$
, 2017 Oxygen-deficient TiO$_2$ in the rutile structure as well as the Ti$_3$O$_5$ Magn{\'e}li phase is investigated within the charge self-consistent combination of density functional theory (DFT) with dynamical mean-field theory (DMFT).
Heckel, Wolfgang +3 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Наукові вісті Національного технічного університету України "Київський політехнічний інститут", 2018 Background. Nitrogen compounds are the most common components of groundwater in Ukraine. Nitrates for humans are not poisonous, but in the human body, they turn into nitrites, affecting the health of the whole organism. One of the possible ways to reduce
Oleksandr V. Kravchenko +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Chemistry Central Journal, 2017 Background A series of rare-earth bisphthalocyanines of praseodymium, samarium and gadolinium bearing 5-bromo-2-thienyl substituents were prepared for the first time.
Jiří Černý +5 more
doaj +1 more source
Vinyl Polymerization by Organoboron Compounds.-Cocatalytic Action of Oxygen and Oxygen Compounds
The Journal of the Society of Chemical Industry, Japan, 1958 トリアルキルホウ素は,ビニル化合物をよく重合させるが,このとき,ビニル基が電気的に,より正になっているような化合物ほど重合速度が大きい。また,トリアルキルホウ素触媒重合においては,酸素あるいは酸素化合物が顕著な助触媒作用をもっていることがわかった。なお,トリアルキルホウ素以外の各種の有機ホウ素化合物を別に合成し,これらの重合触媒能をしらべた結果,触媒活性はホウ素原子上の電子密度の大きさとだいたい平行的であるらしいという結論に達した。しかし,この重合の反応機構については未解の点が多く,なお詳細な研究を必要とする段階にある。
Junji Furukawa +6 more
openaire +2 more sources
Electronic correlations and crystal structure distortions in BaBiO3
, 2012 BaBiO3 is a material where formally Bi4+ ions with the half-filled 6s-states form the alternating set of Bi3+ and Bi5+ ions resulting in a charge ordered insulator.
Anisimov, V. I. +4 more
core +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source