Results 31 to 40 of about 575,029 (266)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

High Oxygen Treatment Increases Antioxidant Capacity and Postharvest Life of Strawberry Fruit

open access: yesFood Technology and Biotechnology, 2007
The antioxidant capacity, total phenolics, volatile compounds, and postharvest quality of strawberry fruit were evaluated after storage in high oxygen atmospheres (40, 60, 80, and 100 kPa) during 14 days at 5 °C.
J. Fernando Ayala-Zavala   +3 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Oxygen is toxic in the cold in C. elegans

open access: yesFrontiers in Physiology
IntroductionTemperature and oxygen are two factors that profoundly affect survival limits of animals; too much or too little of either is lethal.
Cameron M. Suraci   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A simple and efficient method for the preparation of 5-hydroxy-3-acyltetramic acids

open access: yesBeilstein Journal of Organic Chemistry, 2015
Oxidation of the bisenolates of 3-acyltetramic acid to the corresponding 5-hydroxylated compounds using molecular oxygen is reported. The deprotection of the resulting compounds was also achieved.
Johanna Trenner, Evgeny V. Prusov
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Finding a relationship between the composition and the emulsifying character of asphaltenes through FTICR-MS

open access: yesCT&F Ciencia, Tecnología & Futuro
In this work, n-heptane insoluble fractions (asphaltenes) from six crude oils were analyzed by means of Fourier-transform ion cyclotron resonance mass spectrometry (FTICR MS) using both positive Atmospheric Pressure Photo Ionization (+) APPI and negative
Fernando A Rojas-Ruiz   +1 more
doaj   +1 more source

Oxidative Conversion of Methane of Natural Gas to Oxygen Containing Compounds

open access: yesChemical Engineering Transactions, 2017
The search of new compositions of catalysts on carriers on the base of heteropoly compounds of molybdenum for oxidative conversion of methane, the identification of optimal conditions for the partial oxidation of methane to formaldehyde, as well as study
S.A. Tungatarova   +5 more
doaj   +1 more source

Thermal De-Oxygenation to Form Condensable Aerosol From Reconstituted Tobacco without Auto-Ignition

open access: yesContributions to Tobacco and Nicotine Research, 2022
A novel concept is described here that utilizes externally applied heat to a solid rod of reconstituted tobacco biomass to form a stream of aerosol under progressively oxygen-deficient atmosphere.
Guo Zhongya   +18 more
doaj   +1 more source

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