Results 61 to 70 of about 575,029 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Influence of Aeration on the Composition of Biocenosis and Efficiency of Removal of Nitrogen-Containing Compounds on Rapid Filters for Drinking Water Treatment

Наукові вісті Національного технічного університету України "Київський політехнічний інститут", 2018
Background. Nitrogen compounds are the most common components of groundwater in Ukraine. Nitrates for humans are not poisonous, but in the human body, they turn into nitrites, affecting the health of the whole organism. One of the possible ways to reduce
Oleksandr V. Kravchenko, Oleksandr Yu. Galkin, Olena S. Panchenko   +2 more
doaj   +1 more source

Studies of the Oxygenated Compound of Cytochrome Oxidase

Journal of Biological Chemistry, 1968
Abstract Results of rapid reaction experiments indicate that the first observable product formed after the reaction of oxygen with purified reduced cytochrome oxidase is a spectral form which corresponds to that of the oxidized enzyme. The latter is then slowly converted to "The Compound," or so-called oxygenated form.
D C, Wharton, Q H, Gibson
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Oxygen-tolerant Electrochemical CO2 Reduction from Bicarbonate Solutions toward Multicarbon Compounds

Electrochemistry
Electrochemical CO2 reduction to multicarbon products offers a promising pathway for closing the anthropogenic carbon cycle while producing value-added chemicals.
Asato INOUE, Kaito NAGITA, Takashi HARADA, Shuji NAKANISHI, Kazuhide KAMIYA   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Oxygen scavengers as active food packaging: A systematic literature review and network analysis

Food Chemistry Advances
Oxygen scavengers are active packaging materials that extend shelf life and maintain food quality, especially for oxygen-sensitive products. This review examines research trends, innovations, and challenges of oxygen scavengers in packaging from 2000 to ...
Muh Arfan, Andi Dirpan, Adiansyah Syarifuddin, Soumya Majumder   +3 more
doaj   +1 more source