Results 131 to 140 of about 907,608 (354)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Highly Immobilized Bimetallic Fe/M‐N4 (M‐ Mg or Zn) Conductive Metal–Organic Frameworks on Nitrogen‐Doped Porous Carbon for Efficient Electrocatalytic Hydrogen Evolution and Oxygen Reduction Reactions

Small Structures
Herein, a simple method is proposed for developing bimetallic Fe/M‐N4/nitrogen‐doped porous carbon (NPC) (M‐Zn or Mg) conductive metal–organic framework (c‐MOF) composites because of their great potential in replacing conventional catalysts. The prepared
Ravi Nivetha, Mahdieh Razi Asrami, Rajeev Kumar, Sushant Sharma, Milad Jourshabani, Rajaiah Dhilip Kumar, Santhosh Ravichandran, Byeong–Kyu Lee, Youngil Lee, Jin Suk Chung, Sung Gu Kang, Won Mook Choi, Seung Hyun Hur   +12 more
doaj   +1 more source

Core–Shell CoS₂@MoS₂ with Hollow Heterostructure as an Efficient Electrocatalyst for Boosting Oxygen Evolution Reaction

Molecules
It is imperative to develop an efficient catalyst to reduce the energy barrier of electrochemical water decomposition. In this study, a well-designed electrocatalyst featuring a core–shell structure was synthesized with cobalt sulfides as the core and ...
Donglei Guo, Jiaqi Xu, Guilong Liu, Xu Yu   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Hydrothermally Synthesized BiVO4: The Role of KCl as Additive for Improved Photoelectrochemical and Photocatalytic Oxygen Evolution Activity

ChemElectroChem
With sunlight as the most abundant energy source on earth, solar water splitting has the potential to produce renewable hydrogen at a commercially competitive cost.
Jakob Praxmair, Fabrizio Creazzo, Deqi Tang, Jakub Zalesak, Julian Hörndl, Sandra Luber, Simone Pokrant   +6 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Fe‐Induced Electronic Transfer and Structural Evolution of Lotus Pod‐Like CoNiFeP_x@P,N‐C Heterostructure for Sustainable Oxygen Evolution [PDF]

, 2023
Xiaojun Zeng, Qingqing Zhang, Chulong Jin, Hui Huang, Yanfeng Gao   +4 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Chemical production on Mars using in situ propellant production technology [PDF]

In situ propellant production (ISPP) was examined in terms of its applicability to a manned Mars mission. Production of oxygen from Martian atmosphere was used as the baseline system for ISPP technology assessment.
Ash, Robert L.
core   +1 more source