Results 91 to 100 of about 5,587,944 (309)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Formation of Branched Ruthenium Nanoparticles for Improved Electrocatalysis of Oxygen Evolution Reaction

, 2019
Branched nanoparticles are one of the most promising nanoparticle catalysts as their branch sizes and surfaces can be tuned to enable both high activity and stability.
Huber, Dale L, Soshan Cheong, Richard D. Tilley, Gloag, Lucy, Benedetti, Tania M, John Watt, Dale L. Huber, Tania M. Benedetti, Gooding, J Justin, Tilley, Richard D, Watt, John, J. Justin Gooding, Cheong, Soshan, Poerwoprajitno, Agus R, Lucy Gloag, Agus R. Poerwoprajitno   +15 more
core   +1 more source

Local Structural Changes in Polyamorphous (Ni,Fe)Ox Electrocatalysts Suggest a Dual-Site Oxygen Evolution Reaction Mechanism [PDF]

, 2020
Amorphous nickel-iron mixed metal oxides have been shown to be extremely efficient oxygen evolution reaction (OER) electrocatalysts with good stability in alkaline reactionconditions.
Santiago Jimenez, Villegas, Nicholas, Randell, Katelynn, Daly, Roman, Chernikov, Simon, Trudel, Oliver, Calderon, Martin, Schoen   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Electrochemical etching of α-cobalt hydroxide for improvement of oxygen evolution reaction

, 2016
Exploring low-cost and high-efficiency electrocatalysts for oxygen evolution reaction (OER) is of paramount importance to develop large-scale alkaline water-splitting electrolyzers (AWEs).
Yang, Shuang, Zheng, Li Rong, Zhang, Bo, Liu, Peng Fei, Yang, Hua Gui   +4 more
core   +1 more source

The current state of transition metal-based electrocatalysts (oxides, alloys, POMs, and MOFs) for oxygen reduction, oxygen evolution, and hydrogen evolution reactions

Frontiers in Energy Research
Climate change is showing its impacts now more than ever. The intense use of fossil fuels and the resulting CO2 emissions are mainly to blame, accentuating the need to develop further the available energy conversion and storage technologies, which are ...
Henrique Araújo, Henrique Araújo, Biljana Šljukić, Sandra Gago, Diogo M. F. Santos   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficient electrocatalysts derived from praseodymium-doped MOFs and MXene for oxygen reduction, hydrogen evolution, and oxygen evolution reactions

Carbon Trends
In response to the urgent need for high-performance non-precious metal electrocatalysts to address the energy crisis and reduce dependence on fossil fuels, we propose a novel approach to develop a highly selective and efficient electrocatalyst derived ...
Mozhgan Hadavand, Mehdi Mehrpooya, Mohammad Reza Ganjali   +2 more
doaj   +1 more source

Application of Oxygen Reduction Reaction, Oxygen Evolution Reaction and Hydrogen Evolution Reaction in Electrochemical Biosensing

International Journal of Electrochemical Science, 2022
Jianlin Zhou, Ping Qin, Weiyin Liu, Yuwei Liu   +3 more
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source