Results 201 to 210 of about 187,990 (300)

Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis

open access: yesAging Cell, EarlyView.
In aging or fibrotic fibroblasts, NUDT21 is downregulated, leading to alternative polyadenylation/3′ UTR shortening of STAT3 pathway genes, enhancing their protein expression and promoting STAT3 phosphorylation. Activated STAT3 signaling subsequently drives the expression and release of senescence‐associated secretory phenotype (SASP) factors, thereby ...
Jingjing Huang   +14 more
wiley   +1 more source

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review

open access: yesThe American Journal on Addictions, EarlyView.
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi   +4 more
wiley   +1 more source

Fungal‐Driven Airways Dis‐Immunity From Asthma to Allergic Bronchopulmonary Aspergillosis: Dissecting Similarities and Differences

open access: yesAllergy, EarlyView.
ABSTRACT Severe asthma and allergic bronchopulmonary aspergillosis (ABPA) do not rarely coexist and share several similarities in terms of pathobiological background, together with overlapping clinical manifestations, misleading the correct diagnosis. Within that scenario, severe asthma with fungal sensitization (SAFS) further complicates the correct ...
Marco Caminati   +10 more
wiley   +1 more source

New Findings on Pulsatile ECMO: Verification of the Potential to Improve Antithrombogenicity of a Membrane Oxygenator Using Pump‐Generated Pulsatile Flow in an Innovative Animal Model

open access: yesArtificial Organs, EarlyView.
Compared to the steady flow circuit, the pulse flow circuit showed a clear trend of less thrombus formation inside the membrane oxygenator. ABSTRACT Background Extracorporeal membrane oxygenation (ECMO) provides mechanical circulatory and respiratory support.
Hironobu Sakurai   +9 more
wiley   +1 more source

Expert consensus on perioperative management of patients with lung cancer treated with co-ablation system therapy. [PDF]

open access: yesAsia Pac J Oncol Nurs
Xu Y   +11 more
europepmc   +1 more source

Younger Age and Viral Triggers Were Associated With Post‐Infectious Bronchiolitis Obliterans in French Children

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Post‐infectious bronchiolitis obliterans (PIBO) is a rare but severe chronic paediatric obstructive lung disease, characterised by the obliteration of small airways following severe lower respiratory tract infections. Epidemiological data in Europe remain limited. Methods This multicentre retrospective study examined the characteristics of
Julie Mazenq   +24 more
wiley   +1 more source

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