Alveolar mimics with periodic strain and its effect on the cell layer formation [PDF]
Biotechnology and Bioengineering 117(9), 2827-2841 (2020), 2020 We report on the development of a new model of alveolar air-tissue interface on a chip. The model consists of an array of suspended hexagonal monolayers of gelatin nanofibers supported by microframes and a microfluidic device for the patch integration.
arxiv +1 more source
Global and Regional Ventilation during High Flow Nasal Cannula in Patients with Hypoxia [PDF]
Acute and Critical Care, 2018 Background High flow nasal cannula (HFNC) is known to increase global ventilation volume in healthy subjects. We sought to investigate the effect of HFNC on global and regional ventilation patterns in patients with hypoxia.
Dong Hyun Lee +7 more
doaj +1 more source
Acoustic Resonance Effects and Cavitation in SAW Aerosol Generation [PDF]
, 2023 The interaction of surface acoustic waves (SAWs) with liquids enables the production of aerosols with adjustable droplet sizes in the micrometer range expelled from a very compact source. Understanding the nonlinear acousto-hydrodynamics of SAWs with a regulated micro-scale liquid film is essential for acousto-microfluidics platforms, particularly ...
arxiv +1 more source
Micronucleus test in peripheral blood of rats treated with hyperbaric oxygen after subtotal splenectomy preserving the lower pole [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To assess the mutagenic potential of the oxygen inhalation therapy (HBO), by means of the micronucleus test, performed in peripheral blood of rats that underwent subtotal splenectomy with lower pole preservation (ESTPI), after HBO sessions or ...
Marcela Souza Lima Paulo +10 more
doaj +2 more sources
In silico high-resolution whole lung model to predict the locally delivered dose of inhaled drugs [PDF]
arXiv, 2023 The big crux with drug delivery to human lungs is that the delivered dose at the local site of action is unpredictable and very difficult to measure, even a posteriori. It is highly subject-specific as it depends on lung morphology, disease, breathing, and aerosol characteristics.
arxiv
FRET-Amplified Singlet Oxygen Generation by Nanocomposites Comprising Ternary AgInS$_2$/ZnS Quantum Dots and Molecular Photosensitizers [PDF]
, 2023 Antibacterial photodynamic therapy (a-PDT) has emerged as a promising non-invasive therapeutic modality that utilizes the combination of a photosensitive agent, molecular oxygen, and excitation light to generate reactive oxygen species (ROS), demonstrating remarkable activity against multidrug-resistant bacterial infections.
arxiv +1 more source
Does FLASH deplete Oxygen? Experimental Evaluation for Photons, Protons and Carbon Ions [PDF]
, 2021 Purpose: To investigate experimentally, if FLASH irradiation depletes oxygen within water for different radiation types such as photons, protons and carbon ions. Methods: This study presents measurements of the oxygen consumption in sealed, 3D printed water phantoms during irradiation with X-rays, protons and carbon ions at varying dose rates up to ...
arxiv +1 more source
Oxigenoterapia inalatória em idosos internados em um hospital público
Revista Brasileira de Geriatria e GerontologiaResumo Objetivos: Descrever as características da oxigenoterapia inalatória (OI) utilizada em idosos internados no setor de clínica médica de um hospital público brasileiro, bem como verificar o conhecimento dos acompanhantes sobre esta terapia ...
Mariana Colombini Buranello +2 more
doaj +1 more source
Modelling the effect of vascular status on tumour evolution and outcome after thermal therapy [PDF]
arXiv, 2022 Microscale oxygenation plays a prominent role in tumour progression. Spatiotemporal variability of oxygen distribution in the tumour microenvironment contributes to cellular heterogeneity and to the emergence of normoxic and hypoxic populations.
arxiv
Stochastic multi-scale models of competition within heterogeneous cellular populations: simulation methods and mean-field analysis [PDF]
Journal of Theoretical Biology, Volume 407, 21 October 2016, Pages
161-183, 2016 We propose a modelling framework to analyse the stochastic behaviour of heterogeneous, multi-scale cellular populations. We illustrate our methodology with a particular example in which we study a population with an oxygen-regulated proliferation rate. Our formulation is based on an age-dependent stochastic process.
arxiv +1 more source